V. E. Petrova, I. S. Kovalev, G. V. Zyryanov, V. L. Rusinov
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Modification of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide using SNH and click reactions
The applicability of SNH and click reactions in the series of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide and its derivatives for the synthesis of distant analogs of folic acid and fluorophores was studied. The target products were synthesized in the yields up to 81%, and their structures were proved by 1H NMR spectroscopy and mass spectrometry.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.