无功能性肾上腺肿瘤患者的癌症发病率:瑞典基于人口的全国队列研究》。

IF 3 Q2 ENDOCRINOLOGY & METABOLISM Journal of the Endocrine Society Pub Date : 2024-09-13 eCollection Date: 2024-08-27 DOI:10.1210/jendso/bvae154
Jekaterina Patrova, Buster Mannheimer, Martin Larsson, Jonatan D Lindh, Henrik Falhammar
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引用次数: 0

摘要

背景:目前尚不清楚非功能性肾上腺肿瘤(NFAT)是否与较高的癌症发病率有关:分析非功能性肾上腺肿瘤患者的癌症发病率:在这项基于国家登记册的回顾性队列研究中,对 2005-2019 年期间在瑞典发现的连续 NFAT 患者和未患肾上腺肿瘤的匹配对照者进行了长达 15 年的随访。研究结果数据来自国家登记册,并对混杂因素进行了调整。对病例和对照组都进行了随访,直至新诊断出恶性肿瘤、死亡或 2019 年。排除了肾上腺激素过多或曾患恶性肿瘤的患者:在 17 726 例病例中,10 777 例(60.8%)为女性,中位年龄为 65 岁(IQR,57-73)。在 124 366 例对照组中,69 514 例(55.9%)为女性,年龄中位数为 66 岁(IQR,58-73)。与对照组相比,NFAT患者的癌症发病率更高(危险比[HR] 1.35,95% CI 1.29-1.40;调整后的危险比 1.31,95% CI 1.26-1.37)。NFAT与肾上腺癌、甲状腺癌、肺癌、胃癌和小肠癌、肾癌、胰腺癌、乳腺癌和结直肠癌的高发病率有关。敏感性分析没有改变总体结果,但在对NFAT和阑尾炎或胆囊/胆道/胰腺疾病患者进行调整后,相关性没有显著增加。对不明确的良性肿瘤进行调整后,癌症发病率可能被低估:结论:NFAT 患者的癌症发病率有所增加。结论:NFAT 患者的癌症发病率增加,应进行长期随访。
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The Incidence of Cancers in Patients With Nonfunctional Adrenal Tumors: A Swedish Population-Based National Cohort Study.

Context: It is unclear if nonfunctional adrenal tumors (NFAT) are associated with higher cancer incidence.

Objective: To analyze the cancer incidence in patients with NFAT.

Methods: In this national register-based retrospective cohort study, consecutive patients with NFAT identified in Sweden 2005-2019 and matched control individuals without adrenal tumors were followed up to 15 years. Outcome data were collected from national registers and adjusted for confounders. Both cases and controls were followed until newly diagnosed malignancy, death, or until 2019. Individuals with adrenal hormonal excess or prior malignancy were excluded.

Results: Among 17 726 cases, 10 777 (60.8%) were women, and the median age was 65 (IQR, 57-73) years. Among 124 366 controls, 69 514 (55.9%) were women, and the median age was 66 (IQR, 58-73) years. The incidence of any cancer was higher in patients with NFAT compared to controls (hazard ratio [HR] 1.35 95% CI 1.29-1.40; adjusted HR 1.31, 95% CI 1.26-1.37). NFAT was associated with a higher incidence of adrenal, thyroid, lung, stomach and small intestine, kidney, pancreatic, breast, and colorectal cancer. Sensitivity analyses did not change the overall results, but associations were not significantly increased after adjustment in patients with NFAT and appendicitis or gallbladder/biliary tract/pancreas disorders. Cancer incidence may have been underestimated by adjusting for unclear and benign tumors.

Conclusion: The incidence of cancer was increased in patients with NFAT. Long-term follow-up may be indicated.

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来源期刊
Journal of the Endocrine Society
Journal of the Endocrine Society Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.50
自引率
0.00%
发文量
2039
审稿时长
9 weeks
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