传染性脑膜炎和脑炎成人患者的临床表现、风险因素、病因和预后:单中心经验

IF 3.2 Q2 CLINICAL NEUROLOGY Neurology International Pub Date : 2024-09-05 DOI:10.3390/neurolint16050073
Seraj Makkawi, Shatha Alqurashi, Wejdan Hubayni, Saleha Almahdawi, Sadeem Bahkali, Abeer Alharbi, Osama Khojah, Aisha Halawani, Israa Malli
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引用次数: 0

摘要

(1) 背景:中枢神经系统(CNS)感染,包括脑膜炎和脑炎,是与高发病率和高死亡率相关的严重疾病。本研究旨在确定沙特阿拉伯成年患者脑膜炎和脑炎的临床表现、病因和预后,解决目前该人群对这些疾病认识不足的问题。(2) 方法:这是一项单中心回顾性研究,纳入了2016年3月至2022年5月期间确诊为脑膜炎和脑炎的所有成年患者。(3)结果:该研究发现,大多数脑膜炎和脑炎病例都是由未知病原体引起的。71.2%的脑膜炎患者在腰椎穿刺(LP)前接受了抗生素治疗。精神状态改变和癫痫发作是脑炎患者的常见症状,而精神状态改变和发烧则是脑膜炎患者的常见症状。(4) 结论:在治疗脑膜炎和脑炎时必须遵守指南,并及时进行 LP 检查。建立国家生物库,收集疑似脑膜炎或脑炎患者的生物样本,将大大提高我们对沙特阿拉伯这些疾病的了解。
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The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience.

(1) Background: Central nervous system (CNS) infections, including meningitis and encephalitis, are serious conditions which are associated with high morbidity and mortality. This study aims to identify the clinical manifestations, etiologies, and outcomes of meningitis and encephalitis in adult patients in Saudi Arabia, addressing the current gap in understanding these conditions within this population. (2) Methods: This is a single-center retrospective study which included all adult patients diagnosed with meningitis and encephalitis from March 2016 to May 2022. (3) Results: This study found that most cases of meningitis and encephalitis occurred due to unknown pathogens. Pretreatment with antibiotics prior to lumbar puncture (LP) was found in 71.2% of patients with meningitis. Altered mental status and seizures were common presenting symptoms among patients with encephalitis while altered mental status and fever were common among patients with meningitis. (4) Conclusions: Adherence to guidelines in treating meningitis and encephalitis and performing LPs in a timely manner are important. Establishing national biobanks with biological samples from patients suspected of having meningitis or encephalitis will significantly enhance our understanding of these conditions in Saudi Arabia.

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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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