伴有或不伴有忧郁症特征的重度抑郁障碍患者双侧伏隔核的功能连接紊乱

IF 1.6 4区 医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-09-18 DOI:10.1097/WNR.0000000000002097
Hezhi Yan, Zhaosong Chu, Zonglin Shen, Lijin Yuan, Yanru Wu, Yi Lu, Hongyan Jiang, Xiufeng Xu
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引用次数: 0

摘要

我们的研究旨在探讨忧郁型抑郁症患者与非忧郁型抑郁症(NMD)患者之间在伏隔核(NAc)功能连接上的差异及其与忧郁型抑郁症发病机制的关系。我们招募了60名忧郁抑郁症患者、58名非忧郁抑郁症患者和80名健康对照者,他们的性别、年龄和教育程度均匹配。功能连通性分析以双侧 NAc 为研究对象,将其与整个大脑进行比较,并将显著差异与临床评分联系起来。与健康对照组相比,忧郁型抑郁症患者左侧 NAc 与大脑前部区域之间以及右侧 NAc 与颞叶和额叶区域之间的功能连接性降低。相比之下,NMD 患者仅显示出左侧 NAc 与后扣带回皮层之间的功能连接性降低。与 NMD 患者不同的是,忧郁抑郁症患者还表现出右侧 NAc 与额叶中回之间的功能连接性增强。研究结果表明,忧郁型抑郁症患者表现出独特的NAc功能连接模式,尤其是与默认模式网络和前额叶区域的连接,这表明奖赏回路之间存在非典型的相互作用。右侧NAc与前额叶回的连接可能将忧郁抑郁症与NMD区分开来。
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Disrupted functional connectivity of bilateral nucleus accumbens in major depressive disorder with and without melancholic features.

Our study aims to explore the differences in functional connectivity in the nucleus accumbens (NAc) between patients with melancholic depression and non-melancholic depression (NMD) and their relation to melancholic depression's pathogenesis. We recruited 60 melancholic depression, 58 NMD, and 80 healthy controls, all matched for gender, age, and education. Functional connectivity analysis focused on bilateral NAc as the region of interest, comparing it with the whole brain and correlating significant differences with clinical scores. Melancholic depression patients showed reduced functional connectivity between the left NAc and anterior brain regions, and between the right NAc and temporal and frontal areas, compared to healthy controls. In contrast, NMD patients displayed reduced functional connectivity only between the left NAc and the posterior cingulate cortex. Melancholic depression patients also exhibited increased functional connectivity between the right NAc and the middle frontal gyrus, unlike NMD patients. The findings suggest that melancholic depression patients exhibit unique NAc functional connectivity patterns, particularly with the default mode network and prefrontal areas, suggesting atypical reward-circuitry interactions. The right NAc's connection to the prefrontal gyrus may distinguish melancholic depression from NMD.

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来源期刊
Neuroreport
Neuroreport 医学-神经科学
CiteScore
3.20
自引率
0.00%
发文量
150
审稿时长
1 months
期刊介绍: NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.
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