乳酸代谢的现代视角。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-31
J Vavřička, P Brož, D Follprecht, J Novák, A Kroužecký
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引用次数: 0

摘要

乳酸曾被认为是一种代谢废物,如今却被认为是一种在有氧条件下不断形成的重要信号分子。乳酸是一种主要作为糖酵解副产物的分子,近年来由于其在各种生物过程中的多方面作用而变得越来越重要。几个世纪以来,人们一直对乳酸盐存在误解,特别是认为乳酸盐水平升高仅仅是低氧水平造成的,这种观点影响了人们的早期认识。然而,目前的研究对这一观点提出了挑战,并拓展了我们对乳酸盐各种作用的理解。遗憾的是,尽管有上述种种原因,乳酸盐在现代社会中仍是一个令人望而却步的字眼,许多人并不了解它在人体中的价值,更不用说临床应用或体能表现了。本综述的主要目的是刷新当前有关乳酸盐研究的知识,并在专业社会中传播整体信息。关键词:乳酸盐乳酸、乳酸代谢、乳酸、疾病代谢、乳酸穿梭。
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Modern Perspective of Lactate Metabolism.

Once considered a metabolic waste product, today it is considered an important signaling molecule continuously forming under aerobic conditions. Lactate, a molecule primarily known as a byproduct of glycolysis, has gained importance in recent years due to its multifaceted role in various biological processes. Misconceptions surrounding lactate have persisted for centuries, especially the belief that elevated lactate levels were solely a result of low oxygen levels shaped early understanding. However, current research challenges this view and expands our comprehension of lactate's various roles. Unfortunately, despite all of the mentioned above lactate is rooted in modern society as a deterrent word and many people do not know its value in the human body, let alone clinical implementations or physical performance. The main goal of this review is to refresh current knowledge regarding lactate research and spread the overall information among a professional society. Key words: Lactate, Lactate metabolism, Lactic acid, Disease metabolism, Lactate shuttle.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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