[消化系统肿瘤中软骨素相关蛋白的研究进展]。

J N Wu, Y Z Jiang
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引用次数: 0

摘要

消化系统肿瘤是影响人们生活质量的最重要因素之一,已成为全球严重的公共卫生问题。对肿瘤高危人群进行肿瘤标志物的早期筛查和干预是预防肿瘤的关键。绒毛膜促性腺激素相关蛋白(FRP)是绒毛膜促性腺激素家族的重要成员,此类蛋白参与了生殖系统和呼吸系统等肿瘤的病理过程。近年来,FRP在消化系统肿瘤的研究中引起了广泛关注,提示FRP可能在消化系统肿瘤的发生发展中起着重要作用,是临床诊断和治疗的潜在标志物。文章综述了与消化系统肿瘤相关的 FRP 的生物学功能、表达及潜在作用机制,以期为消化系统肿瘤的诊断和预防、预后评估及药物开发提供参考。
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[Research progress of follistatin-related proteins in digestive system tumors].

Tumors of the digestive system are one of the most important factors affecting people's quality of life and have become a serious public health problem globally.Early screening and intervention of tumor markers in high-risk groups for tumors is the key to tumor prevention. Follistatin-related proteins (FRP) are important members of the follistatin family and such proteins are involved in the pathological process of tumors of the reproductive system and respiratory system, among others. In recent years, FRP has attracted extensive attention in the study of digestive system tumors, suggesting that FRP may play a significant role in the development of digestive system tumors, and is a potential marker for clinical diagnosis and treatment. The article reviews the biological function, expression and potential mechanism of action of FRP associated with digestive system tumors, with a view to providing reference for the diagnosis and prevention of digestive system tumors, prognosis assessment and drug development.

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来源期刊
中华预防医学杂志
中华预防医学杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
12678
期刊介绍: Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.
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