[短肽专属肠内营养疗法对克罗恩病患儿体格生长和营养状况的影响]。

Min Yang, Run-Qiu Wu, Wen-Xin Chen, Xue Qiao, Hui Yang
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引用次数: 0

摘要

研究目的评估短肽专属肠内营养(EEN)治疗诱导活动性克罗恩病(CD)患儿缓解的临床疗效,以及治疗前后体格生长和营养指标的变化:一项前瞻性研究纳入了2017年1月至2024年1月南京医科大学附属儿童医院消化内科收治的43名活动性CD患儿。参与者被随机分为药物治疗组(13名儿童)和短肽+药物治疗组(30名儿童)。分析两组治疗前后小儿克罗恩病活动指数(PCDAI)评分、体格生长和营养指标的变化:结果:短肽+药物治疗组的PCDAI评分在治疗后低于药物治疗组(PPP结论:短肽EEN治疗可以改善小儿克罗恩病患者的体格发育和营养状况:短肽EEN疗法可诱导活动性CD患儿的临床缓解,促进其身体发育,同时改善其营养状况。
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[Impact of short-peptide exclusive enteral nutrition therapy on physical growth and nutritional status in children with Crohn's disease].

Objectives: To evaluate the clinical efficacy of short-peptide exclusive enteral nutrition (EEN) therapy in inducing remission during active Crohn's disease (CD) in children, as well as changes in physical growth and nutritional indicators before and after treatment.

Methods: A prospective study included 43 children with active CD who were admitted to the Department of Gastroenterology, Children's Hospital of Nanjing Medical University from January 2017 to January 2024. The participants were randomly divided into a medication treatment group (13 children) and a short-peptide + medication treatment group (30 children). The changes in the Pediatric Crohn's Disease Activity Index (PCDAI) scores, physical growth, and nutritional indicators before and after treatment were analyzed in both groups.

Results: The PCDAI scores in the short-peptide + medication treatment group were lower than those in the medication treatment group after treatment (P<0.05). The Z-scores for weight-for-age, body mass index, and albumin levels were higher in the short-peptide + medication treatment group compared to the medication treatment group (P<0.05). In the patients with moderate to severe CD, total protein levels in the short-peptide + medication treatment group were significantly higher than those in the medication treatment group (P<0.05).

Conclusions: Short-peptide EEN therapy can induce clinical remission in children with active CD and promote their physical growth while improving their nutritional status.

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来源期刊
中国当代儿科杂志
中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.50
自引率
0.00%
发文量
5006
期刊介绍: The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R;ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.
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