肠道移植:免疫反应的意义

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2024-09-17 DOI:10.1016/j.ajg.2024.08.001
Sara Assadiasl, Mohammad Hossein Nicknam
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引用次数: 0

摘要

肠道异体移植有许多常驻免疫细胞,而且是受者循环淋巴细胞的目的地,因此似乎是最具挑战性的实体器官移植。肠道移植后急性排斥反应发生率高,致命的移植物抗宿主病(GvHD)报告频发,因此需要开展更多的研究来描述移植后并发症免疫发病机制的分子机制,从而确定新的治疗目标。此外,随着免疫抑制剂的快速发展,现在是时候考虑采用新的治疗方法来治疗难治性排斥反应或严重 GvHD 患者了。本文介绍了肠道移植前后的主要免疫学挑战,包括脑死亡供体炎症、急性排斥反应、抗体介导的慢性排斥反应以及 GvHD。此外,还综述了在实验和临床环境中用于改善肠道异体移植耐受性的新型免疫疗法,以及操作性耐受的案例。
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Intestinal transplantation: Significance of immune responses.

Intestinal allografts, with many resident immune cells and as a destination for circulating lymphocytes of the recipient, appear to be the most challenging solid organ transplants. The high incidence of acute rejection and frequent reports of fatal graft-versus-host disease (GvHD) after intestinal transplantation call for more research to describe the molecular mechanisms involved in the immunopathogenesis of post-transplant complications to define new therapeutic targets. In addition, according to the rapid development of immunosuppressive agents, it is time to consider novel therapeutic approaches in managing treatment-refractory patients with rejection or severe GvHD. Herein, the main immunological challenges before and after intestinal transplant including, brain-dead donor inflammation, acute rejection, antibody-mediated, and chronic rejections, as well as GvHD have been described. Besides, the new immune-based therapies used in experimental and clinical settings to improve tolerance toward intestinal allograft, and cases of operational tolerance have been reviewed.

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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
期刊最新文献
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