就 "2-甲氧基雌二醇通过下调 HIF-1α 使抗他莫昔芬的 MCF-7 乳腺癌细胞变得敏感 "发表评论

IF 2.3 4区医学 Q2 SURGERY Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-09-21 DOI:10.1016/j.surge.2024.09.004

Hethesh Chellapandian, Sivakamavalli Jeyachandran

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引用次数: 0

摘要

本研究探讨了2-甲氧基雌二醇（2-ME）通过下调缺氧诱导因子1α（HIF-1α）克服MCF-7乳腺癌细胞对他莫昔芬（TAM）耐药性的潜力。作者通过一系列体外实验证明，将2-ME与TAM结合可增强对耐药细胞的细胞毒性作用，增加细胞凋亡标志物，并降低胆固醇和甘油三酯水平。虽然这些研究结果突显了一种很有前景的治疗方法，但体内或临床数据的缺乏限制了其直接的临床应用。未来的研究应侧重于在动物模型中验证这些结果，并探索长期疗效和分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comment on, “2-methoxyestradiol sensitizes tamoxifen-resistant MCF-7 breast cancer cells via downregulating HIF-1α”

This study investigates the potential of 2-methoxyestradiol (2-ME) to overcome tamoxifen (TAM) resistance in MCF-7 breast cancer cells by downregulating hypoxia-inducible factor 1 alpha (HIF-1α). Through a series of in vitro experiments, the authors demonstrate that combining 2-ME with TAM enhances the cytotoxic effects on resistant cells, increases apoptosis markers, and reduces cholesterol and triglyceride levels. While the findings highlight a promising therapeutic approach, the lack of in vivo or clinical data limits direct clinical application. Future research should focus on validating these results in animal models and exploring long-term efficacy and molecular mechanisms.

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来源期刊

Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 医学-外科

CiteScore

4.40

自引率

0.00%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Since its establishment in 2003, The Surgeon has established itself as one of the leading multidisciplinary surgical titles, both in print and online. The Surgeon is published for the worldwide surgical and dental communities. The goal of the Journal is to achieve wider national and international recognition, through a commitment to excellence in original research. In addition, both Colleges see the Journal as an important educational service, and consequently there is a particular focus on post-graduate development. Much of our educational role will continue to be achieved through publishing expanded review articles by leaders in their field. Articles in related areas to surgery and dentistry, such as healthcare management and education, are also welcomed. We aim to educate, entertain, give insight into new surgical techniques and technology, and provide a forum for debate and discussion.