Huan Liu, Sumei Qin, Hongyan Zhang, Zhongyin Chen, Yiwei Zhao, Jia Liu, Yan Deng, Miaodeng Liu, Wei Chen, Zheng Wang, Lin Wang
{"title":"基于丝胶蛋白的 ROS 活性氧生成微针平台可促进血管生成并减少炎症,促进无疤痕糖尿病伤口愈合","authors":"Huan Liu, Sumei Qin, Hongyan Zhang, Zhongyin Chen, Yiwei Zhao, Jia Liu, Yan Deng, Miaodeng Liu, Wei Chen, Zheng Wang, Lin Wang","doi":"10.1002/adfm.202404461","DOIUrl":null,"url":null,"abstract":"Diabetic foot ulcer typically undergoes a delayed wound-healing process owing to the disordered microenvironment, including persistent inflammation, long-term hypoxia, and excessive fibrosis, eventually leading to severe disabilities and other poor outcomes. However, current strategies cannot meet the dynamic demands during the wound-healing process. Herein, a reactive oxygen species (ROS)–responsive oxygen-generating microneedle platform, consisting of a sericin-based glucose-responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under a highly oxidative microenvironment, the functionalized sericin protein depletes overproduced ROS to generate oxygen, which can not only alleviate the hypoxic microenvironment and promote angiogenesis by activating extracellular signal-regulated kinase and Heme Oxygenase-1 pathways but also decrease the expression of proinflammatory cytokines. Moreover, the hyperglycaemic condition triggers the gradual dissociation of this microneedle platform and promotes the release of verteporfin to enhance scarless re-epithelization via inhibiting the yes-associated protein signal. This versatile sericin microneedle system integrates advantageous features including inflammation alleviation, angiogenesis promotion, and scar inhibition capabilities, accelerates diabetic wound repair in vivo, and offers a novel approach for oxygen self-supply and wound microenvironment remodeling.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Silk Sericin-based ROS-Responsive Oxygen Generating Microneedle Platform Promotes Angiogenesis and Decreases Inflammation for Scarless Diabetic Wound Healing\",\"authors\":\"Huan Liu, Sumei Qin, Hongyan Zhang, Zhongyin Chen, Yiwei Zhao, Jia Liu, Yan Deng, Miaodeng Liu, Wei Chen, Zheng Wang, Lin Wang\",\"doi\":\"10.1002/adfm.202404461\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Diabetic foot ulcer typically undergoes a delayed wound-healing process owing to the disordered microenvironment, including persistent inflammation, long-term hypoxia, and excessive fibrosis, eventually leading to severe disabilities and other poor outcomes. However, current strategies cannot meet the dynamic demands during the wound-healing process. Herein, a reactive oxygen species (ROS)–responsive oxygen-generating microneedle platform, consisting of a sericin-based glucose-responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under a highly oxidative microenvironment, the functionalized sericin protein depletes overproduced ROS to generate oxygen, which can not only alleviate the hypoxic microenvironment and promote angiogenesis by activating extracellular signal-regulated kinase and Heme Oxygenase-1 pathways but also decrease the expression of proinflammatory cytokines. Moreover, the hyperglycaemic condition triggers the gradual dissociation of this microneedle platform and promotes the release of verteporfin to enhance scarless re-epithelization via inhibiting the yes-associated protein signal. This versatile sericin microneedle system integrates advantageous features including inflammation alleviation, angiogenesis promotion, and scar inhibition capabilities, accelerates diabetic wound repair in vivo, and offers a novel approach for oxygen self-supply and wound microenvironment remodeling.\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.5000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/adfm.202404461\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adfm.202404461","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Silk Sericin-based ROS-Responsive Oxygen Generating Microneedle Platform Promotes Angiogenesis and Decreases Inflammation for Scarless Diabetic Wound Healing
Diabetic foot ulcer typically undergoes a delayed wound-healing process owing to the disordered microenvironment, including persistent inflammation, long-term hypoxia, and excessive fibrosis, eventually leading to severe disabilities and other poor outcomes. However, current strategies cannot meet the dynamic demands during the wound-healing process. Herein, a reactive oxygen species (ROS)–responsive oxygen-generating microneedle platform, consisting of a sericin-based glucose-responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under a highly oxidative microenvironment, the functionalized sericin protein depletes overproduced ROS to generate oxygen, which can not only alleviate the hypoxic microenvironment and promote angiogenesis by activating extracellular signal-regulated kinase and Heme Oxygenase-1 pathways but also decrease the expression of proinflammatory cytokines. Moreover, the hyperglycaemic condition triggers the gradual dissociation of this microneedle platform and promotes the release of verteporfin to enhance scarless re-epithelization via inhibiting the yes-associated protein signal. This versatile sericin microneedle system integrates advantageous features including inflammation alleviation, angiogenesis promotion, and scar inhibition capabilities, accelerates diabetic wound repair in vivo, and offers a novel approach for oxygen self-supply and wound microenvironment remodeling.
期刊介绍:
Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.