Lepidium cartilagineum (J. C. Mayer) Thell.非挥发性化合物的植物化学和药理学研究及其花和果实精油成分的测定

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-09-23 DOI:10.1016/j.fitote.2024.106236
Csilla Zsuzsanna Dávid , Zuhao Cui , Katalin Veres , Annamária Kincses , Norbert Kúsz , Anita Barta , Tamara Sápi , László Bakacsy , Judit Hohmann , Andrea Vasas
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引用次数: 0

摘要

从软骨草全草的甲醇提取物中分离出了 18 种化合物,其中包括苯丙酸类化合物(1-2)、新木脂素类化合物(3-9)、巨木脂素类化合物(10)、苯基葡萄糖苷类化合物(11)、黄酮类化合物(12-14)和含 N 的化合物(15-18)。通过核磁共振和质谱测定确定了这些化合物的结构。利用气相色谱和气相色谱-质谱测量法研究了从软骨草花和果实中制备的精油的成分。精油富含脂肪醛和碳氢化合物,但含硫化合物(如异硫氰酸盐)含量较低。从该植物的气生部分和根部制备的提取物、精油和分离出的化合物(1-9)对 COLO 205 和 COLO 320 细胞系进行了抗增殖活性测试,并对鼠李糖乳杆菌进行了抗菌活性测试。脱氢二烯醇 γ'-甲醚(5)对两种人类肿瘤细胞株都具有明显的抗增殖活性。提取物和化合物都不影响细菌的生长,也不影响鼠李糖杆菌生物膜的形成。根据上述结果,可以得出结论:软骨草对形成鼠李糖的人体肠道微生物群无毒性。
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Phytochemical and pharmacological investigation of the non-volatile compounds of Lepidium cartilagineum (J. C. Mayer) Thell. and determination of the essential oil composition of its flowers and fruits
Eighteen compounds, among them phenylpropanoids (12), neolignans (39), a megastigmane (10), a phenyl glucoside (11), flavonoids (1214), and N-containing compounds (1518) were isolated from the methanolic extract of the whole plant of L. cartilagineum. The structures of the compounds were determined by NMR and MS measurements. The composition of the essential oils prepared from the flowers and fruits of L. cartilagineum was investigated using GC and GC–MS measurements. The essential oils were rich in aliphatic aldehydes and hydrocarbons, but low in sulfur-containing compounds, e.g., isothiocyanates. The extracts prepared from the aerial parts and roots of the plant, the essential oil, and the isolated compounds (19) were tested for antiproliferative activity against COLO 205 and COLO 320 cell lines and antibacterial activity on Lactobacillus rhamnosus. Dehydrodiconiferyl alcohol γ’-methyl ether (5) possessed marked antiproliferative activity against both human tumor cell lines. Neither the extracts nor the compounds affected the growth of the bacteria and did not influence the biofilm formation of L. rhamnosus. Based on the results, it can be concluded that L. cartilagineum is non-toxic to the human gut microbiome forming L. rhamnosus.
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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