威尼斯泻湖的神经退化和衰老:海洋无脊椎动物 Botryllus schlosseri。

IF 4.1 Q1 CLINICAL NEUROLOGY Brain communications Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae257
Tommaso Bocci, Chiara Anselmi, Federico La Torre, Emanuela De Lisa, Giacomo Sabbadin, Matteo Guidetti, Natale Maiorana, Alberto Priori, Lucia Manni
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引用次数: 0

摘要

在这项工作中,作者提出了一种研究人类神经退行性疾病的新颖而有趣的动物模型--Botryllus schlosseri,这是一种栖息于全球温带海域的小型无脊椎动物,它与哺乳动物在涉及病理衰老的基因表达方面有着显著的相似之处。
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Lessons on neurodegeneration and aging from the Lagoon of Venice: the marine invertebrate Botryllus schlosseri.

In this work, the authors proposed a novel and interesting animal model for studying human neurodegenerative diseases, Botryllus schlosseri, a small invertebrate inhabiting temperate seas worldwide, which shares remarkable similarities with mammals in the expression of genes involved in pathological aging.

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