通过可穿戴激光多普勒血流测量仪分布式系统检测糖尿病患者的微循环功能障碍。

Journal of biophotonics Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1002/jbio.202400297
Elena Zharkikh, Yulia Loktionova, Andrey Dunaev
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引用次数: 0

摘要

本文利用分布式可穿戴激光多普勒血流分析仪系统,对糖尿病(DM)患者上下肢不同皮肤区域的血流灌注和激光多普勒血流测量仪(LDF)信号的幅频频谱进行了研究。对手指、脚趾、手腕和小腿部位进行了 LDF 测量。对平均灌注值、内皮、神经、肌源、呼吸和心脏频率范围内的血流振荡幅度以及营养血流值进行了分析。结果显示,DM 患者下肢的组织灌注量和营养血流量减少,而上肢的组织灌注量和营养血流量增加。同时还观察到内皮振荡和神经源振荡的振幅减小。这些结果证实了使用可穿戴 LDF 分析仪检测正常和病理情况下血流调节差异的可能性。
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Microcirculatory Dysfunction in Patients With Diabetes Mellitus Detected by a Distributed System of Wearable Laser Doppler Flowmetry Analysers.

The paper is devoted to the study of perfusion and amplitude-frequency spectra of laser Doppler flowmetry (LDF) signals in patients with diabetes mellitus (DM) in different skin areas of the upper and lower extremities using a distributed system of wearable LDF analysers. LDF measurements were performed in the areas of the fingers, toes, wrists and shins. The mean perfusion values, the amplitudes of blood flow oscillations in endothelial, neurogenic, myogenic, respiratory and cardiac frequency ranges, and the values of nutritive blood flow were analysed. The results revealed a decrease in tissue perfusion and nutritive blood flow in the lower extremities and an increase in these parameters in the upper extremities in patients with DM. A decrease in the amplitudes of endothelial and neurogenic oscillations was observed. The obtained results confirm the possibility of using wearable LDF analysers to detect differences in the blood flow regulation in normal and pathological conditions.

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