肺癌脑转移分布的相关因素:一项回顾性研究。

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-10-01 DOI:10.1007/s10585-024-10315-0
Yixin Hu, Weiwei Lei, Enhui Xin, Tan Cheng, Jiang Liu, Yu Tang, Yong Lai, Hong Yu, Yong Tan, Jing Yang, Junhao Huang, Daihong Liu, Jiuquan Zhang
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引用次数: 0

摘要

肺癌患者脑转移灶(BMs)的分布可能与原发肿瘤相关因素和脑小血管病(CSVDs)有关。本研究旨在探讨上述因素对脑转移灶分布的潜在影响。研究共纳入了 823 名肺癌 BM 患者的 5788 个病灶。测定了 15 个脑区的 BMs 和 CSVDs 数量。CSVD包括近期皮层下小梗塞(RSSI)、血管周围间隙和假定血管源性腔隙(LPVO)。我们收集了伴有BMs的肺癌患者的CSVD数量和主要肿瘤相关因素(包括临床和影像学特征)。我们利用单变量和多变量线性回归分析了上述因素对 15 个脑区 BMs 数量的潜在影响。此外,我们还对所有腺癌(AD)患者、女性腺癌患者、男性腺癌患者和小细胞肺癌患者进行了亚组分析。单变量线性回归分析表明,骨转移、肾上腺转移、RSSIs 和 LPVOs 与半数以上受检脑区的 BMs 数量相关。在多变量线性回归分析中,只有LVPOs的独立相关性依然存在,在亚组分析中也发现了类似的现象。总之,肺癌患者的BMs分布似乎与LVPO的存在有关,而原发性肿瘤相关因素的影响较小。
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Factors associated with the distribution of brain metastases in lung cancer: a retrospective study.

The distribution of brain metastases (BMs) in patients with lung cancer may be associated with the primary tumor-related factors and cerebral small vascular diseases (CSVDs). The aim of this study was to investigate the potential effects of the above factors on the distribution of BMs. A total of 5,788 lesions in 823 patients with BMs from lung cancer were enrolled. The numbers of BMs and CSVDs in 15 brain regions were determined. CSVDs include recent small subcortical infarcts (RSSIs), perivascular spaces, and lacunes of presumed vascular origin (LPVOs). We collected the number of CSVDs, and primary tumor-related factors (including clinical and imaging features) in lung cancer patients with BMs. Univariate and multivariate linear regression were utilized to analyze the potential influence of the above factors on the number of BMs in 15 brain regions. In addition, we performed subgroup analyses of all patients with adenocarcinoma (AD), female patients with AD, male patients with AD, and patients with small cell lung cancer. Univariate linear regression analyses showed that bone metastasis, adrenal metastasis, RSSIs, and LPVOs were associated with the number of BMs in over half of the examined brain regions. Only the independent association of LVPOs persisted in the multivariate linear regression analyses, and similar phenomenon was found in the subgroup analyses. In conclusion, the distribution of BMs in lung cancer patients appears to be associated with the presence of LVPOs, while primary tumor-related factors have less influence.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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