Norharmane 可增强丙咪嗪和西酞普兰诱导的抗焦虑和抗抑郁类似反应:异全息图分析。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI:10.1097/FBP.0000000000000794
Fatemeh Khakpai
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引用次数: 0

摘要

β-咔啉化合物具有治疗抑郁和焦虑行为的特性。丙咪嗪和西酞普兰在调节焦虑和抑郁行为方面发挥着重要作用。我们研究了去甲哈曼、丙咪嗪和西酞普兰对焦虑和抑郁样效应的影响及其相互作用。我们采用高架迷宫和强迫游泳试验来评估雄性小鼠的焦虑和抑郁样行为。结果显示,腹腔注射诺和曼(10 毫克/千克)可增加高架加迷宫试验中的开臂时间百分比(%OAT),减少强迫游泳试验中的不动时间,这表明诺和曼具有抗焦虑和抗抑郁样作用。注射丙咪嗪(5 毫克/千克;静脉注射)可提高 OAT 百分率并缩短不动时间,这表明丙咪嗪具有抗焦虑和抗抑郁作用。此外,去甲哈曼还能增强丙咪嗪诱导的抗焦虑和抗抑郁类反应,增加OAT百分比,减少静止时间。研究结果表明,在小鼠体内,去甲哈曼和丙咪嗪具有相加的抗焦虑和抗抑郁作用。单独服用西酞普兰(5 毫克/千克;静注)可提高小鼠的瞳孔散大率并缩短静止时间,从而产生类似抗焦虑和抗抑郁的作用。如果同时注射西酞普兰和去甲哈曼,去甲哈曼会增强西酞普兰诱导的抗焦虑和抗抑郁类似效应,增加OAT百分比并缩短不动时间。这些结果表明,诺马烷和抗抑郁药物(如丙咪嗪和西酞普兰)在调节小鼠焦虑和抑郁过程方面具有相加的抗焦虑和抗抑郁作用。
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Norharmane potentiated anxiolytic- and antidepressant-like responses induced by imipramine and citalopram: an isobologram analysis.

β-carboline compounds display a therapeutic property for treating depression and anxiety behaviors. Imipramine and citalopram play an important role in the modulation of anxiety and depression behaviors. We investigated the effects of norharmane, imipramine, and citalopram on anxiety- and depression-like effects and their interactions. Elevated plus maze and forced swimming test were used for the assessment of anxiety- and depression-like behaviors in male mice. The results revealed that intraperitoneal (i.p.) administration of norharmane (10 mg/kg) increased percentage of open arm time (%OAT) in the elevated plus maze test and decreased immobility time in the forced swimming test, proposing anxiolytic- and antidepressant-like effects. Injection of imipramine (5 mg/kg; i.p.) enhanced %OAT and decreased immobility time, suggesting anxiolytic- and antidepressant-like effects. Moreover, norharmane potentiated the anxiolytic- and antidepressant-like responses induced by imipramine by increasing %OAT and decreasing immobility time. The results revealed additive anxiolytic- and antidepressant-like effects between norharmane and imipramine in mice. Alone, the administration of citalopram (5 mg/kg; i.p.) enhanced %OAT and reduced immobility time, causing anxiolytic- and antidepressant-like effects. When citalopram and norharmane were coinjected, norharmane augmented the anxiolytic- and antidepressant-like effects induced by citalopram by increasing %OAT and reducing immobility time. These results indicated additive anxiolytic- and antidepressant-like effects between norharmane and antidepressant drugs such as imipramine and citalopram on the modulation of anxiety and depression processes in mice.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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