连接癌症患者的大脑和身体

IF 7.5 1区生物学 Q1 CELL BIOLOGY Genes & development Pub Date : 2024-10-16 DOI:10.1101/gad.352300.124

Michael Cross, Andrew Dillin, Thales Papagiannakopoulos

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引用次数: 0

摘要

最近的研究突显了脑-体轴不仅在维持机体平衡方面，而且在协调机体对免疫和炎症损伤的反应方面所发挥的核心作用。在这里，我们将讨论科学是如何准备好应对大脑直接参与疾病的多种方式的。特别是，我们认为将神经科学的尖端工具与转化相关的癌症模型相结合，对于理解大脑和肿瘤如何相互沟通和调节行为至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bridging brain and body in cancer.

Recent work has highlighted the central role the brain-body axis plays in not only maintaining organismal homeostasis but also coordinating the body's response to immune and inflammatory insults. Here, we discuss how science is poised to address the many ways that our brain is directly involved with disease. In particular, we feel that combining cutting-edge tools in neuroscience with translationally relevant models of cancer will be critical to understanding how the brain and tumors communicate and modulate each other's behavior.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).