{"title":"头颈部癌症与阻塞性睡眠呼吸暂停之间关系的叙述性综述:临床研究和统计分析。","authors":"","doi":"10.1016/j.smrv.2024.102010","DOIUrl":null,"url":null,"abstract":"<div><div>Obstructive sleep apnea (OSA) is an underestimated and overlooked comorbidity in head and neck cancer (HNC) care. Refining HNC-OSA management requires an improved grasp of the HNC-OSA relationship. Thus, this paper reviews the current course of HNC therapy, causal and associative relationships before and after treatment, and statistical methods quantifying HNC-OSA interactions. This evaluation serves a dual purpose: to support oncologists and sleep physicians in improving the treatment outcomes of patients undergoing <span>HNC</span> treatment by considering <span>OSA</span> as a comorbidity and to assist researchers in selecting suitable analytical models for investigating the correlation between <span>OSA</span> and <span>HNC</span>. The investigation confirms a positive correlation between the apnea-hypopnea index (AHI) and primary tumor size, consistent with prior findings. Case studies also reported new evidence of lipoma and head-neck tumors triggering OSA, and sleep apnea surgery prompting tumor development. This paper provides an overview of existing statistical models and offers suggestions for model selection and a framework for designing experiments that delve into research questions surrounding the link between OSA and HNC across various stages of cancer treatment. Despite progress, understanding the HNC-OSA interplay remains incomplete due to limited histological, molecular, and clinical data. Future studies with longitudinal data are crucial for comprehensive insights.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":null,"pages":null},"PeriodicalIF":11.2000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A narrative review of the relationship between head and neck cancer and obstructive sleep apnea: Clinical studies and statistical analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.smrv.2024.102010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Obstructive sleep apnea (OSA) is an underestimated and overlooked comorbidity in head and neck cancer (HNC) care. Refining HNC-OSA management requires an improved grasp of the HNC-OSA relationship. Thus, this paper reviews the current course of HNC therapy, causal and associative relationships before and after treatment, and statistical methods quantifying HNC-OSA interactions. This evaluation serves a dual purpose: to support oncologists and sleep physicians in improving the treatment outcomes of patients undergoing <span>HNC</span> treatment by considering <span>OSA</span> as a comorbidity and to assist researchers in selecting suitable analytical models for investigating the correlation between <span>OSA</span> and <span>HNC</span>. The investigation confirms a positive correlation between the apnea-hypopnea index (AHI) and primary tumor size, consistent with prior findings. Case studies also reported new evidence of lipoma and head-neck tumors triggering OSA, and sleep apnea surgery prompting tumor development. This paper provides an overview of existing statistical models and offers suggestions for model selection and a framework for designing experiments that delve into research questions surrounding the link between OSA and HNC across various stages of cancer treatment. Despite progress, understanding the HNC-OSA interplay remains incomplete due to limited histological, molecular, and clinical data. Future studies with longitudinal data are crucial for comprehensive insights.</div></div>\",\"PeriodicalId\":49513,\"journal\":{\"name\":\"Sleep Medicine Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":11.2000,\"publicationDate\":\"2024-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sleep Medicine Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S108707922400114X\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep Medicine Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S108707922400114X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
阻塞性睡眠呼吸暂停(OSA)是头颈癌(HNC)治疗中被低估和忽视的合并症。完善 HNC-OSA 管理需要更好地掌握 HNC-OSA 的关系。因此,本文回顾了当前的 HNC 治疗过程、治疗前后的因果关系和关联关系,以及量化 HNC-OSA 相互作用的统计方法。该评估具有双重目的:支持肿瘤医生和睡眠医生将 OSA 视为合并症,从而改善接受 HNC 治疗的患者的治疗效果;协助研究人员选择合适的分析模型,以调查 OSA 与 HNC 之间的相关性。调查证实,呼吸暂停-低通气指数(AHI)与原发性肿瘤大小呈正相关,这与之前的研究结果一致。病例研究还报告了脂肪瘤和头颈部肿瘤引发 OSA 以及睡眠呼吸暂停手术促使肿瘤发生的新证据。本文概述了现有的统计模型,并提出了选择模型的建议和设计实验的框架,以深入探讨围绕 OSA 和 HNC 在癌症治疗各个阶段的联系的研究问题。尽管取得了进展,但由于组织学、分子学和临床数据有限,对 HNC-OSA 相互作用的了解仍不全面。未来的纵向数据研究对于全面了解情况至关重要。
A narrative review of the relationship between head and neck cancer and obstructive sleep apnea: Clinical studies and statistical analysis
Obstructive sleep apnea (OSA) is an underestimated and overlooked comorbidity in head and neck cancer (HNC) care. Refining HNC-OSA management requires an improved grasp of the HNC-OSA relationship. Thus, this paper reviews the current course of HNC therapy, causal and associative relationships before and after treatment, and statistical methods quantifying HNC-OSA interactions. This evaluation serves a dual purpose: to support oncologists and sleep physicians in improving the treatment outcomes of patients undergoing HNC treatment by considering OSA as a comorbidity and to assist researchers in selecting suitable analytical models for investigating the correlation between OSA and HNC. The investigation confirms a positive correlation between the apnea-hypopnea index (AHI) and primary tumor size, consistent with prior findings. Case studies also reported new evidence of lipoma and head-neck tumors triggering OSA, and sleep apnea surgery prompting tumor development. This paper provides an overview of existing statistical models and offers suggestions for model selection and a framework for designing experiments that delve into research questions surrounding the link between OSA and HNC across various stages of cancer treatment. Despite progress, understanding the HNC-OSA interplay remains incomplete due to limited histological, molecular, and clinical data. Future studies with longitudinal data are crucial for comprehensive insights.
期刊介绍:
Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels.
Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine.
The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.