DEAD-box 蛋白在少突胶质细胞发育、分化和稳态中的多种功能。

IF 4.2 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Neurochemistry Pub Date : 2024-10-07 DOI:10.1111/jnc.16238
Norihisa Bizen, Hirohide Takebayashi
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引用次数: 0

摘要

少突胶质细胞是中枢神经系统中的一种胶质细胞,在轴突周围髓鞘的形成、促进盐传导和保持神经轴突的完整性方面起着至关重要的作用。少突胶质细胞分化和稳态失调与多种神经系统疾病有关,包括髓鞘发育不良症(如佩里泽斯-默茨巴赫病)、脱髓鞘疾病(如多发性硬化症)、阿尔茨海默病和精神疾病。因此,揭示少突胶质细胞的发育、分化和稳态机制对于了解这些疾病的发病机制和开发治疗干预措施至关重要。大量研究发现并分析了转录因子、RNA 代谢因子、翻译控制因子以及细胞内和细胞外信号的功能,它们参与了从少突胶质细胞命运决定到终末分化的一系列过程。DEAD-box 蛋白是一种多功能 RNA 螺旋酶,可调控包括转录、RNA 处理和翻译在内的各种细胞内过程,它们在少突胶质细胞的发育、分化和维持稳态等各方面发挥的不同作用日益得到认可。这篇综述介绍了有关 DEAD-box 蛋白介导的少突胶质细胞生物学调控网络的最新见解。
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Diverse functions of DEAD-box proteins in oligodendrocyte development, differentiation, and homeostasis.

Oligodendrocytes, a type of glial cell in the central nervous system, have a critical role in the formation of myelin around axons, facilitating saltatory conduction, and maintaining the integrity of nerve axons. The dysregulation of oligodendrocyte differentiation and homeostasis have been implicated in a wide range of neurological diseases, including dysmyelinating disorders (e.g., Pelizaeus-Merzbacher disease), demyelinating diseases (e.g., multiple sclerosis), Alzheimer's disease, and psychiatric disorders. Therefore, unraveling the mechanisms of oligodendrocyte development, differentiation, and homeostasis is essential for understanding the pathogenesis of these diseases and the development of therapeutic interventions. Numerous studies have identified and analyzed the functions of transcription factors, RNA metabolic factors, translation control factors, and intracellular and extracellular signals involved in the series of processes from oligodendrocyte fate determination to terminal differentiation. DEAD-box proteins, multifunctional RNA helicases that regulate various intracellular processes, including transcription, RNA processing, and translation, are increasingly recognized for their diverse roles in various aspects of oligodendrocyte development, differentiation, and maintenance of homeostasis. This review introduces the latest insights into the regulatory networks of oligodendrocyte biology mediated by DEAD-box proteins.

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来源期刊
Journal of Neurochemistry
Journal of Neurochemistry 医学-神经科学
CiteScore
9.30
自引率
2.10%
发文量
181
审稿时长
2.2 months
期刊介绍: Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.
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