槲皮素及其纳米制剂在癌症治疗中的单一或联合疗法的疗效:分子机制的最新进展

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI:10.1155/2024/5594462
Tanzila Akter Eity, Md Shimul Bhuia, Raihan Chowdhury, Shakil Ahmmed, Salehin Sheikh, Rima Akter, Muhammad Torequl Islam
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引用次数: 0

摘要

槲皮素是黄酮醇亚类的主要代表,几乎所有可食用的蔬菜和水果中都含有丰富的槲皮素。槲皮素具有显著的治疗特性,能防止脂质过氧化,对多种退行性疾病有益。槲皮素对动脉粥样硬化和慢性炎症等多种疾病有益。本研究旨在发现槲皮素的抗癌活性,并确定其抗癌作用的不同机制和途径。研究还揭示了槲皮素的生物制药、毒理学特征和临床应用,以评估其是否适合作为一种可靠的抗癌药物进行进一步研究。本综述使用不同的科学搜索引擎收集了有关该化合物与癌症的所有相关数据,包括 PubMed、Springer Link、Wiley Online、Web of Science、SciFinder、ScienceDirect 和 Google Scholar。综述显示,槲皮素具有很强的抗癌特性,包括针对各种癌症的细胞凋亡、细胞增殖抑制、自噬、细胞周期停滞、血管生成抑制以及侵袭和迁移抑制。研究结果还显示,槲皮素能显著缓和和调节不同的通路,包括PI3K/AKT-mTORC1通路、JAK/STAT信号系统、MAPK信号通路、MMP信号通路、NF-κB通路和p-Camk2/p-DRP1通路。然而,这项研究发现,槲皮素的口服生物利用度较低,原因是吸收率降低;应用纳米技术(槲皮素的纳米制剂)可克服这一限制。此外,不同的调查显示,槲皮素对调查对象没有毒性作用。根据这些研究结果,槲皮素可被视为治疗不同癌症的一种可靠的候选化疗药物。不过,建议开展更多临床研究,以确定适当的疗效、安全性和人体剂量。
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Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono- or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms.

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties and was beneficial in numerous degenerative diseases by preventing lipid peroxidation. Quercetin is beneficial in different diseases, such as atherosclerosis and chronic inflammation. This study aims to find out the anticancer activities of quercetin and to determine different mechanisms and pathways which are responsible for the anticancer effect. It also revealed the biopharmaceutical, toxicological characteristics, and clinical utilization of quercetin to evaluate its suitability for further investigations as a reliable anticancer drug. All of the relevant data concerning this compound with cancer was collected using different scientific search engines, including PubMed, Springer Link, Wiley Online, Web of Science, SciFinder, ScienceDirect, and Google Scholar. This review demonstrated that quercetin showed strong anticancer properties, including apoptosis, inhibition of cell proliferation, autophagy, cell cycle arrest, inhibition of angiogenesis, and inhibition of invasion and migration against various types of cancer. Findings also revealed that quercetin could significantly moderate and regulate different pathways, including PI3K/AKT-mTORC1 pathway, JAK/STAT signaling system, MAPK signaling pathway, MMP signaling pathway, NF-κB pathway, and p-Camk2/p-DRP1 pathway. However, this study found that quercetin showed poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of quercetin). Moreover, different investigations revealed that quercetin expressed no toxic effect in the investigated subjects. Based on the view of these findings, it is demonstrated that quercetin might be considered a reliable chemotherapeutic drug candidate in the treatment of different cancers. However, more clinical studies are suggested to establish the proper therapeutic efficacy, safety, and human dose.

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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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