自闭症谱系障碍及其背后的各种机制。

IF 3.3 3区 心理学 Q1 BEHAVIORAL SCIENCES Pharmacology Biochemistry and Behavior Pub Date : 2024-10-06 DOI:10.1016/j.pbb.2024.173887
Parisa Rajabi , Ali Sabbah Noori , Javad Sargolzaei
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引用次数: 0

摘要

自闭症谱系障碍(ASD)是一种复杂的异质性神经发育疾病,以一系列社交、沟通和行为挑战为特征。本综合评论深入探讨了 ASD 的主要方面。临床概述和遗传特征提供了对 ASD 的基本认识,强调了导致其复杂性的临床表现和遗传基础。我们探讨了在 ASD 中起作用的错综复杂的神经生物学机制,包括结构和功能上的差异,这些差异可能是该病症标志性特征的基础。新近的研究揭示了免疫系统和神经炎症在 ASD 中的作用。本节探讨了免疫因素与 ASD 之间的潜在联系,为了解 ASD 的病理生理学提供了见解。我们研究了非典型功能连接和神经递质系统的改变是如何导致 ASD 独特的认知和行为特征的。为了寻求有效的干预措施,本节回顾了当前的治疗策略,从行为和教育干预到药物治疗方法,让我们一窥 ASD 治疗的多样性和不断发展的前景。对 ASD 机制的全面探索旨在促进我们对该疾病不断发展的理解,并指导为 ASD 患者开发更有针对性和个性化的干预措施。
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Autism spectrum disorder and various mechanisms behind it
Autism Spectrum Disorder (ASD) is a complex and heterogeneous neurodevelopmental condition characterized by a range of social, communicative, and behavioral challenges. This comprehensive review delves into key aspects of ASD. Clinical Overview and genetic features provide a foundational understanding of ASD, highlighting the clinical presentation and genetic underpinnings that contribute to its complexity. We explore the intricate neurobiological mechanisms at play in ASD, including structural and functional differences that may underlie the condition's hallmark traits. Emerging research has shed light on the role of the immune system and neuroinflammation in ASD. This section investigates the potential links between immunological factors and ASD, offering insights into the condition's pathophysiology. We examine how atypical functional connectivity and alterations in neurotransmitter systems may contribute to the unique cognitive and behavioral features of ASD. In the pursuit of effective interventions, this section reviews current therapeutic strategies, ranging from behavioral and educational interventions to pharmacological approaches, providing a glimpse into the diverse and evolving landscape of ASD treatment. This holistic exploration of mechanisms in ASD aims to contribute to our evolving understanding of the condition and to guide the development of more targeted and personalized interventions for individuals living with ASD.
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来源期刊
CiteScore
6.40
自引率
2.80%
发文量
122
审稿时长
38 days
期刊介绍: Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.
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