神经性病毒的免疫逃避机制

IF 9 2区 医学 Q1 VIROLOGY Reviews in Medical Virology Pub Date : 2024-11-01 DOI:10.1002/rmv.2589
Yayun Yan, Yu Sun, Xinyuan Guo, Yuanchao An, Ying Chang
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引用次数: 0

摘要

感染中枢神经系统的病毒所带来的持续挑战在于它们躲避宿主免疫系统的复杂能力。这篇综述探讨了这些神经性病毒所采用的复杂的免疫逃避机制,重点是它们对宿主免疫反应的调节、对适应性免疫的逃避,以及使其能够持续存在的细胞和分子策略。探讨的主要领域包括病毒潜伏期和再活化、抑制细胞凋亡和抗原变异,并详细研究了病毒蛋白及其与宿主细胞过程的相互作用。
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Immune Evasion Mechanism of Neurotropic Viruses.

The persistent challenge posed by viruses that infect the central nervous system lies in their sophisticated ability to evade the host immune system. This review explores into the complex mechanisms of immune evasion employed by these neurotropic viruses, focussing on their modulation of host immune responses, evasion of adaptive immunity, and the cellular and molecular strategies that enable their persistence. Key areas explored include viral latency and reactivation, the inhibition of apoptosis, and antigenic variation, with a detailed examination of viral proteins and their interactions with host cellular processes.

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来源期刊
Reviews in Medical Virology
Reviews in Medical Virology 医学-病毒学
CiteScore
21.40
自引率
0.90%
发文量
88
期刊介绍: Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.
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