实验性缺血性中风中电针相关脑可塑性的系统回顾和元分析。

X U Yingshan, W U Chunxiao, Y U Wei, Guo Hongji, L U Liming, X U Nenggui, Tang Chunzhi
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引用次数: 0

摘要

目的:系统评估电针在缺血性中风引起的脑损伤中维持脑可塑性的作用:系统评估电针在缺血性中风介导的脑损伤中维持脑可塑性的作用:我们从七个数据库中检索了截至 2022 年 10 月 7 日发表的所有相关试验。使用 CAMARADES 偏倚风险工具评估方法学质量。使用Review Manager v.5.3软件对比较效应进行了元分析:共纳入 101 项研究,涉及 2148 只动物。对于大多数研究,Meta 分析的主要结果显示,与非 EA 治疗相比,EA 能显著改善缺血性中风大鼠突触后密度厚度[标准化平均差(SMD)= 1.41,95% 置信区间(CI)(0.59,2.23),P = 0.0008]、突触数值密度[SMD = 1.55,95% CI(0.48,2.63),P = 0.005]。同样,与对照组相比,EA能改善突触、神经发生、血管生成和神经营养素活性等生物标志物的部分指标(P 0.05):现有证据表明,EA 可通过大脑可塑性调节缺血性中风。结论:现有证据表明,EA 可通过脑可塑性调节缺血性中风,未来应开展更严格、更高质量的研究。
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Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke.

Objective: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.

Methods: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.

Results: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference (SMD) = 1.41, 95% confidence interval (CI) (0.59, 2.23), P = 0.0008], numerical density of synapses [SMD = 1.55, 95% CI (0.48, 2.63), P = 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (P < 0.05).

Conclusion: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.

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