{"title":"膀胱肿瘤中的衰老基质成纤维细胞支持癌症进展。","authors":"","doi":"10.1038/s43587-024-00738-5","DOIUrl":null,"url":null,"abstract":"Aging is associated with biological processes (such as the accumulation of senescent cells) that are relevant to the development of cancer. Using genetically modified mouse models, we discovered that p16high senescent cells with a secretory phenotype accumulate in the bladder during aging, which leads to cancer progression.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 11","pages":"1527-1528"},"PeriodicalIF":17.0000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Senescent stromal fibroblasts in bladder tumors support cancer progression\",\"authors\":\"\",\"doi\":\"10.1038/s43587-024-00738-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aging is associated with biological processes (such as the accumulation of senescent cells) that are relevant to the development of cancer. Using genetically modified mouse models, we discovered that p16high senescent cells with a secretory phenotype accumulate in the bladder during aging, which leads to cancer progression.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"4 11\",\"pages\":\"1527-1528\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00738-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00738-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Senescent stromal fibroblasts in bladder tumors support cancer progression
Aging is associated with biological processes (such as the accumulation of senescent cells) that are relevant to the development of cancer. Using genetically modified mouse models, we discovered that p16high senescent cells with a secretory phenotype accumulate in the bladder during aging, which leads to cancer progression.
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