靶向 IL-30 的免疫脂质体

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-10-10 DOI:10.1038/s41585-024-00958-9
Louise Lloyd
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引用次数: 0

摘要

发表在《实验与分子医学》(Experimental & Molecular Medicine)上的一项研究证明了治疗前列腺癌的现代安全免疫纳米疗法的概念。研究人员使用微流控装置设计并合成了一种涂有 PEG(NxP)的非免疫原性生物相容性阳离子脂质纳米复合物。这些纳米脂质体装载了Cas9引导RNA-人IL-30复合物(用于删除IL30,已知IL30具有肿瘤促进潜能,在前列腺癌中高度表达),然后与抗人前列腺癌特异性前列腺干细胞抗原(PSCA)抗体结合。这些免疫脂质体被称为 Cas9gRNA-hIL30-hPSCA NxPs。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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