Strategy for C–H Functionalization of Cubanes: From Stoichiometric Reaction to Catalytic Methodology

We summarized a strategy for C–H functionalization of cubanes, highlighting recent progress in the field. Cubane, known as a bioisostere of benzene ring, and its functionalization hold significant potential for future drug development. However, owing to its highly strained and thermodynamically unstable nature, the methodologies are limited and their precise and diverse functionalization is challenging in current organic chemistry. In this Concept, we categorized and explained these methodologies, which represents a majority of current cubane C–H functionalization. In addition, we discussed recent advancements in catalytic C–H functionalization methods, demonstrating their potential to address these challenges effectively.