雄激素受体通过改变 miR23a-3p/EPHB2 通路促进肺癌转移

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current Medical Science Pub Date : 2024-10-01 Epub Date: 2024-10-11 DOI:10.1007/s11596-024-2891-1

Yan Yang, Jing-Wen Huang, Wei-Wei Yu

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引用次数: 0

摘要

目的：本研究旨在探讨男性肺癌患者的生存率低于女性肺癌患者的原因：本研究旨在探讨男性肺癌患者生存率低于女性肺癌患者的原因：本研究通过Argonaute免疫沉淀、荧光素酶测定和ChIP等多种技术，证实了雄激素受体（AR）在不同体外细胞系和体内小鼠模型中对肺癌细胞侵袭的积极作用：结果：研究结果表明，AR通过改变蛋白表达水平上的EPHB2信号增强了肺癌细胞的侵袭，而这反过来又需要miRNA-23a-3p的变化。恢复miRNA-23a-3p可抵消AR介导的肺癌细胞侵袭的加强：这项研究揭示了AR可能通过调节miRNA-23a-3p/EPHB2信号来促进肺癌的母细胞转移，靶向这一信号通路可为抑制肺癌转移提供新的方法。

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Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the miR23a-3p/EPHB2 Pathway.

Objective: This study aimed to investigate the reasons behind the lower survival rates in male lung cancer patients than in female lung cancer patients.

Methods: Through various techniques, such as Argonaute immunoprecipitation, luciferase assays, and ChIP, this study confirmed the positive effects of androgen receptor (AR) on lung cancer cell invasion across different in vitro cell lines and in vivo mouse models.

Results: The findings suggest that AR enhanced the invasion of lung cancer cells by modifying EPHB2 signals at the protein expression level, which in turn required changes in miRNA-23a-3p. Restoring miRNA-23a-3p could counteract the intensified invasion of lung cancer cells mediated by AR.

Conclusion: This study revealed that AR may facilitate the lung cancer matastasis by modulating miRNA-23a-3p/EPHB2 signaling and that targeting this signaling pathway could provide new approaches to inhibit lung cancer metastasis.

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.