低强度经颅超声刺激可调节阿尔茨海默病小鼠模型的神经血管耦合。

IF 2.9 2区医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2024-10-03 DOI:10.1093/cercor/bhae413

Xin Li, Qiaoxuan Wang, Mengran Wang, Zhenfang Ma, Yi Yuan

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引用次数: 0

摘要

神经血管耦合在阿尔茨海默病的发展过程中起着重要作用。然而，目前还不清楚超声刺激如何调节阿尔茨海默病的神经血管耦合。在这里，我们发现：(i) 经颅超声刺激能调节阿尔茨海默病小鼠脑血氧代谢的时域和频域特征；(ii) 经颅超声刺激能显著调节阿尔茨海默病小鼠局部场电位的θ和γ频率的相对功率；(iii) 经颅超声刺激能显著调节阿尔茨海默病小鼠前爪电刺激诱导的时域和频域神经血管耦合。这为经颅超声刺激在阿尔茨海默病患者中的临床应用提供了研究基础。

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Low-intensity transcranial ultrasound stimulation modulates neurovascular coupling in mouse models of Alzheimer's disease.

Neurovascular coupling plays an important role in the progression of Alzheimer's disease. However, it is unclear how ultrasound stimulation modulates neurovascular coupling in Alzheimer's disease. Here, we found that (i) transcranial ultrasound stimulation modulates the time domain and frequency domain characteristics of cerebral blood oxygen metabolism in Alzheimer's disease mice; (ii) transcranial ultrasound stimulation can significantly modulate the relative power of theta and gamma frequency of local field potential in Alzheimer's disease mice; and (iii) transcranial ultrasound stimulation can significantly modulate the neurovascular coupling in time domain and frequency domain induced by forepaw electrical stimulation in Alzheimer's disease mice. It provides a research basis for the clinical application of transcranial ultrasound stimulation in Alzheimer's disease patients.

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.

期刊最新文献

My science and career with Joseph E. LeDoux. Individual differences in functional connectivity during suppression of imagined threat. When emotion and time meet from human and rodent perspectives: a central role for the amygdala? Introspective psychophysics for the study of subjective experience. Examining threat responses through a developmental lens.