A. V. Bogdanov, A. A. Ivanova, A. D. Voloshina, R. R. Rakhmatullin, A. V. Samorodov, Z. A. Valiullina, I. D. Krylova, S. V. Bukharov
{"title":"基于芳基取代的异汀类和 2-氯乙炔基 (4-(二甲基氨基)苯基)(2-肼基-2-氧代乙基)膦酸酯的杂化化合物的合成与抗肿瘤活性","authors":"A. V. Bogdanov, A. A. Ivanova, A. D. Voloshina, R. R. Rakhmatullin, A. V. Samorodov, Z. A. Valiullina, I. D. Krylova, S. V. Bukharov","doi":"10.1134/S1070363224080085","DOIUrl":null,"url":null,"abstract":"<p>New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 8","pages":"1962 - 1966"},"PeriodicalIF":0.9000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate\",\"authors\":\"A. V. Bogdanov, A. A. Ivanova, A. D. Voloshina, R. R. Rakhmatullin, A. V. Samorodov, Z. A. Valiullina, I. D. Krylova, S. V. Bukharov\",\"doi\":\"10.1134/S1070363224080085\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells.</p>\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"94 8\",\"pages\":\"1962 - 1966\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070363224080085\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363224080085","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate
New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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