A. E. Miroslavov, P. M. Kuz’menko, M. Yu. Tyupina, A. P. Sakhonenkova, G. V. Sidorenko, A. R. Kochergina, S. A. Krotov
{"title":"具有 N,N'-三价配体和 14-异氰基-3-甲基十四酸甲酯的 \"2+1B \"锝-99m 三羰基配合物","authors":"A. E. Miroslavov, P. M. Kuz’menko, M. Yu. Tyupina, A. P. Sakhonenkova, G. V. Sidorenko, A. R. Kochergina, S. A. Krotov","doi":"10.1134/S1066362224040143","DOIUrl":null,"url":null,"abstract":"<p>A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. “2+1<sub>B</sub>” tricarbonyl complexes [<sup>99<i>m</i></sup>Tc(CO)<sub>3</sub>(N^N)CN(CH<sub>2</sub>)<sub>11</sub>CH(CH<sub>3</sub>)CH<sub>2</sub>COOMe]<sup>+</sup>, where N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [<sup>99<i>m</i></sup>Tc(CO)<sub>3</sub>(N^N)(H<sub>2</sub>O,EtOH)]<sup>+</sup> with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99<i>m</i> complexes was confirmed by HPLC, and the partition coefficient (<i>n</i>-octanol/water) of these complexes was measured.</p>","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"66 4","pages":"522 - 530"},"PeriodicalIF":0.9000,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"“2+1B” Technetium-99m Tricarbonyl Complexes with N,N'-Bidentate Ligands and Methyl 14-Isocyano-3-methyltetradecanoate\",\"authors\":\"A. E. Miroslavov, P. M. Kuz’menko, M. Yu. Tyupina, A. P. Sakhonenkova, G. V. Sidorenko, A. R. Kochergina, S. A. Krotov\",\"doi\":\"10.1134/S1066362224040143\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. “2+1<sub>B</sub>” tricarbonyl complexes [<sup>99<i>m</i></sup>Tc(CO)<sub>3</sub>(N^N)CN(CH<sub>2</sub>)<sub>11</sub>CH(CH<sub>3</sub>)CH<sub>2</sub>COOMe]<sup>+</sup>, where N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [<sup>99<i>m</i></sup>Tc(CO)<sub>3</sub>(N^N)(H<sub>2</sub>O,EtOH)]<sup>+</sup> with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99<i>m</i> complexes was confirmed by HPLC, and the partition coefficient (<i>n</i>-octanol/water) of these complexes was measured.</p>\",\"PeriodicalId\":747,\"journal\":{\"name\":\"Radiochemistry\",\"volume\":\"66 4\",\"pages\":\"522 - 530\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1066362224040143\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiochemistry","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S1066362224040143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
“2+1B” Technetium-99m Tricarbonyl Complexes with N,N'-Bidentate Ligands and Methyl 14-Isocyano-3-methyltetradecanoate
A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. “2+1B” tricarbonyl complexes [99mTc(CO)3(N^N)CN(CH2)11CH(CH3)CH2COOMe]+, where N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [99mTc(CO)3(N^N)(H2O,EtOH)]+ with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes was confirmed by HPLC, and the partition coefficient (n-octanol/water) of these complexes was measured.
期刊介绍：
Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.
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