β-CF3-1,3-烯酰胺的分子间区域选择性氢酰胺化：一种制备三取代γ-CF3-烯酰胺的方法

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-10-14 DOI:10.1002/ejoc.202400674

Yuxuan Cao, Zongxiang Yu, Yizhen Chen, Lu Liu, Yuanjing Xiao

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引用次数: 0

摘要

本研究开发了一种简单的碱介导的、高区域选择性的 1,4-氢酰胺化β-CF3-1,3-烯酰胺与仲酰胺合成三取代γ-CF3-烯酰胺化合物的方法。一般来说，N-烷基磺酰胺是进行本转化的良好候选化合物。γ-CF3-烯酰胺可用于合成潜在的高附加值化合物，如氟化卤代吡咯、四氢喹啉和 2-CF3-putrescine 衍生物。

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Regioselective Intermolecular Hydroamidation of β-CF3-1,3-enynamides: An Approach to Tri-substituted γ-CF3-allenamides

A simple base mediated, highly regioselective 1,4-hydroamidation of β-CF3-1,3-enynamides with secondary amides for synthesis of tri-substituted γ-CF3-allenamides compounds was developed. N-alkyl sulfonamides are generally good candidates for the present transformation. γ-CF3-allenamides could be employed for synthesis of potential value-added compounds such as fluorinated halogenated pyrrole, tetrahydroquinoline and 2-CF3-putrescine derivatives.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.