比利时鸟类和哺乳动物中携带 TR34/L98H 的临床曲霉分离物的泛唑抗性

IF 4.1 2区医学 Q1 INFECTIOUS DISEASES One Health Pub Date : 2024-10-02 DOI:10.1016/j.onehlt.2024.100907

Hanne Debergh , Roel Haesendonck , Nadine Botteldoorn , An Martel , Frank Pasmans , Claude Saegerman , Ann Packeu

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引用次数: 0

摘要

曲霉菌病对鸟类和哺乳动物的健康都有重大危害。由于延误诊断和治疗失败，这些感染的治疗效果往往很差。我们调查了比利时鸟类和哺乳动物的 152 例曲霉菌病病例。大多数样本来自有尾目（40.1%）和鸽形目（19.7%）。五个分离菌株（3.3%）显示出对至少一种医用唑类的表型耐药性。其中 3 个分离物具有 TR34/L98H 突变的泛唑抗药性。这种耐药性突变的普遍存在证明了环境是接触和耐药性选择的途径，突出了 "同一健康 "概念的重要性。

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Pan-azole resistance in clinical Aspergillus fumigatus isolates carrying TR34/L98H from birds and mammals in Belgium

Aspergillosis causes significant health risks to both birds and mammals. The outcome of these infections is often poor due to delayed diagnosis and treatment failure. We investigated 152 cases of aspergillosis from birds and mammals in Belgium. Most samples originated from the taxonomic orders Artiodactyla (40.1 %) and Columbiformes (19.7 %). Five isolates (3.3 %) showed phenotypical resistance against at least one medical azole. Three of these isolates were pan-azole resistant bearing the TR34/L98H mutation. The predominance of this resistance mutation supports an environmental route for exposure and resistance selection, highlighting the importance of the One Health concept.

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来源期刊

One Health Medicine-Infectious Diseases

CiteScore

8.10

自引率

4.00%

发文量

审稿时长

18 weeks

期刊介绍： One Health - a Gold Open Access journal. The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information. Submissions to the following categories are welcome: Virology, Bacteriology, Parasitology, Mycology, Vectors and vector-borne diseases, Co-infections and co-morbidities, Disease spatial surveillance, Modelling, Tropical Health, Discovery, Ecosystem Health, Public Health.