铜催化 2-卤苯甲酸和 2-氟-1,3-二酮环化合成 4-氟异香豆素

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Journal of Fluorine Chemistry Pub Date : 2024-10-09 DOI:10.1016/j.jfluchem.2024.110355

Haruki Sakagami, Akira Tsubouchi, Akio Saito

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引用次数: 0

摘要

含氟杂环由于其独特的性质，在医药、农用化学品和材料化学领域大有可为。然而，尽管含氟异香豆素具有非常有用的潜在结构，但其合成方法仍然是一个具有挑战性的课题。在此，我们介绍了通过现成的 2-卤代苯甲酸和 2-氟-1,3-二酮的串联偶联-环化-酰化反应合成氟化异香豆素的方法。这项研究提供了为数不多的氟化异香豆素的合成方法之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 4-fluoroisocoumarins by copper-catalyzed annulation of 2-halobenzoic acids and 2-fluoro-1,3-diketones

Fluorinated heterocycles have been promising in the field of medicinal, agrochemical and materials chemistry due to their unique properties. However, despite the potentially very useful structures of fluorinated isocoumarins, the synthetic method of fluorinated isocoumarins remains a challenging topic. Herein, we describe the synthetic method of fluorinated isocoumarins by tandem coupling-cyclization-deacylation reaction of readily available 2-halobenzoic acids and 2-fluoro-1,3-diketones. This study provides one of the few synthetic methods of fluorinated isocoumarins.

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.