人类中脑器官组织：帕金森病高级建模和治疗探索的有力工具

IF 6.7 1区医学 Q1 NEUROSCIENCES NPJ Parkinson's Disease Pub Date : 2024-10-20 DOI:10.1038/s41531-024-00799-8

Xin Cui, Xinwei Li, Huimin Zheng, Yun Su, Shuyu Zhang, Mengjie Li, Xiaoyan Hao, Shuo Zhang, Zhengwei Hu, Zongping Xia, Changhe Shi, Yuming Xu, Chengyuan Mao

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引用次数: 0

摘要

帕金森病（PD）是一种以黑质多巴胺能神经元缺失为特征的神经退行性疾病。尽管研究取得了进展，但发病机制仍不清楚。人中脑器官组织（hMLOs）已成为研究帕金森病、药物筛选和潜在治疗方法的一种有前途的模型。这篇综述讨论了 hMLOs 的发展、其在帕金森病研究中的应用以及目前在类器官构建中面临的挑战，并强调了可能的优化策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human midbrain organoids: a powerful tool for advanced Parkinson’s disease modeling and therapy exploration

Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains unclear. Human midbrain organoids (hMLOs) have emerged as a promising model for studying PD, drug screening, and potential treatments. This review discusses the development of hMLOs, their application in PD research, and current challenges in organoid construction, highlighting possible optimization strategies.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.