Rafael Costa E Campos, Rayssa Ruszkowski do Amaral, Marta Ribeiro Hentschke, Marcelo Garcia Toneto, Carlos Eduardo Poli-de-Figueiredo
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Likewise, hyperparathyroidism is associated to progressive loss of renal function, with increased phosphate and decrease calcium levels, which induce the secretion of parathyroid hormone.</p><p><strong>Objectives: </strong>To translate into Portuguese (Brazil), culturally adapt and validate the questionnaire Parathyroid Symptoms Assessment (PAS), following reliability and validity criteria in patients with chronic kidney disease and hyperparathyroidism.</p><p><strong>Methods: </strong>Methodological and cross-sectional study, carried out at São Lucas Hospital/PUCRS, Porto Alegre, Brazil. The PAS questionnaire validation process followed protocols from previous studies. After translating into Portuguese, it was applied to 100 patients with secondary (SHPT) and tertiary or persistent (THPT) hyperparathyroidism. For PAS validation data, patients responded to the Short Form Health 36 (SF-36) questionnaire. Reliability criteria were evaluated using intraclass correlation coefficient (ICC) and Cronbach's alpha (α-C). Validity was assessed by Spearman's correlation coefficient between PAS and SF-36 values.</p><p><strong>Results: </strong>Participant's mean age was 55.6 ± 15.6 years, 61% was male, and 68% was diagnosed with SHPT. Among 100 patients, 53% performed a PAS retest (ICC = 0.83). The internal reliability by α-C was 0.86. Negative correlations were observed between PAS questions and SF-36 physical and mental domains, which ranged from 0.3 to 0.7.</p><p><strong>Conclusion: </strong>The Brazilian version of the PAS questionnaire was found to be valid and reliable. 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Likewise, hyperparathyroidism is associated to progressive loss of renal function, with increased phosphate and decrease calcium levels, which induce the secretion of parathyroid hormone.</p><p><strong>Objectives: </strong>To translate into Portuguese (Brazil), culturally adapt and validate the questionnaire Parathyroid Symptoms Assessment (PAS), following reliability and validity criteria in patients with chronic kidney disease and hyperparathyroidism.</p><p><strong>Methods: </strong>Methodological and cross-sectional study, carried out at São Lucas Hospital/PUCRS, Porto Alegre, Brazil. The PAS questionnaire validation process followed protocols from previous studies. After translating into Portuguese, it was applied to 100 patients with secondary (SHPT) and tertiary or persistent (THPT) hyperparathyroidism. For PAS validation data, patients responded to the Short Form Health 36 (SF-36) questionnaire. 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引用次数: 0
摘要
导言:慢性肾脏病(CKD)与高发病率、高死亡率和生活质量下降有关。同样,甲状旁腺机能亢进症也与肾功能逐渐丧失、磷酸盐增加和钙水平下降有关,这些因素会诱发甲状旁腺激素的分泌:将甲状旁腺症状评估(PAS)问卷翻译成葡萄牙语(巴西),并按照可靠性和有效性标准对其进行文化适应性调整和验证,适用于慢性肾病和甲状旁腺功能亢进症患者:方法:在巴西阿雷格里港的圣卢卡斯医院/PUCRS开展横断面研究。PAS 问卷的验证过程遵循了以往研究的规程。在翻译成葡萄牙语后,对100名继发性(SHPT)和三级或持续性(THPT)甲状旁腺机能亢进症患者进行了问卷调查。对于 PAS 验证数据,患者回答了健康简表 36(SF-36)问卷。可靠性标准采用类内相关系数(ICC)和克朗巴赫α(α-C)进行评估。通过 PAS 和 SF-36 值之间的斯皮尔曼相关系数评估有效性:参与者的平均年龄为 55.6 ± 15.6 岁,61% 为男性,68% 被诊断为 SHPT。在 100 名患者中,53% 进行了 PAS 重测(ICC = 0.83)。α-C内部信度为0.86。PAS问题与SF-36身体和精神领域之间存在负相关,相关范围为0.3至0.7:巴西版 PAS 问卷有效且可靠。PAS问卷可用于评估讲葡萄牙语的巴西甲状旁腺功能亢进症患者的生活质量。
Translation into Portuguese (Brazil), cultural adaptation and validation of Parathyroid Assessment of Symptoms (PAS) in patients with chronic kidney disease and hyperparathyroidism.
Introduction: Chronic kidney disease (CKD) is related to high morbidity and mortality and loss of quality of life. Likewise, hyperparathyroidism is associated to progressive loss of renal function, with increased phosphate and decrease calcium levels, which induce the secretion of parathyroid hormone.
Objectives: To translate into Portuguese (Brazil), culturally adapt and validate the questionnaire Parathyroid Symptoms Assessment (PAS), following reliability and validity criteria in patients with chronic kidney disease and hyperparathyroidism.
Methods: Methodological and cross-sectional study, carried out at São Lucas Hospital/PUCRS, Porto Alegre, Brazil. The PAS questionnaire validation process followed protocols from previous studies. After translating into Portuguese, it was applied to 100 patients with secondary (SHPT) and tertiary or persistent (THPT) hyperparathyroidism. For PAS validation data, patients responded to the Short Form Health 36 (SF-36) questionnaire. Reliability criteria were evaluated using intraclass correlation coefficient (ICC) and Cronbach's alpha (α-C). Validity was assessed by Spearman's correlation coefficient between PAS and SF-36 values.
Results: Participant's mean age was 55.6 ± 15.6 years, 61% was male, and 68% was diagnosed with SHPT. Among 100 patients, 53% performed a PAS retest (ICC = 0.83). The internal reliability by α-C was 0.86. Negative correlations were observed between PAS questions and SF-36 physical and mental domains, which ranged from 0.3 to 0.7.
Conclusion: The Brazilian version of the PAS questionnaire was found to be valid and reliable. The PAS questionnaire can be used to evaluate quality of life in Brazilian patients with hyperparathyroidism who speak Portuguese.