韩国中年人的食物摄入量与血清芳香烃受体配体活性之间的关系。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS Nutrition Research and Practice Pub Date : 2024-10-01 Epub Date: 2024-09-09 DOI:10.4162/nrp.2024.18.5.711
Kyungho Ha, Hoonsung Choi, Youngmi Kim Pak, Hong Kyu Lee, Hyojee Joung
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引用次数: 0

摘要

背景/目的:饮食是暴露于干扰内分泌的化学品(EDCs)的一个重要途径。然而,很少有研究调查韩国人的膳食摄入量与 EDC 暴露水平之间的关系。在早前的一项研究中,我们发现血清中芳基烃受体配体(AhRLs)的生物活性可以作为替代生物标志物来表明暴露于 EDCs 的情况,而且它们会抑制线粒体功能。我们还发现,通过细胞内三磷酸腺苷(MIS-ATP)和活性氧(MIS-ROS)水平确定的血清线粒体抑制物质(MIS)可以作为暴露于 EDCs 的生物标志物,因为它们与 AhRL 和血液中的 EDCs 水平有很强的相关性。在此,我们研究了韩国中年人食用特定食物与 EDCs 的替代血清生物标志物(即 AhRL、MIS-ATP 和 MIS-ROS)之间的关系:纳入了韩国基因组与流行病学研究安星队列中 45-76 岁的 1 466 名参与者。采用半定量食物频率问卷调查法测量了包括肉类、鱼类、蔬菜和水果在内的食物摄入量:鱼类摄入量与 AhRL 呈正相关(β = 0.0035,P = 0.0166),而十字花科蔬菜摄入量与 AhRL 呈负相关(β = -0.0007,P = 0.0488)。十字花科蔬菜摄入量与 MIS-ATP 水平呈正相关(β = 0.0051,P = 0.0420)。鱼类摄入量越高,AhRL 偏高的风险越高(三等分:几率比 [OR],1.49;95% 置信区间 (CIs),1.08-2.06;趋势 P = 0.0305)。此外,十字花科蔬菜摄入量第二高的三等分组出现 AhRL 偏高的几率低于最低的三等分组(OR,0.73;95% CIs,0.54-0.97),但未观察到明显的线性趋势:结论:摄入不同类型的食物可能与韩国中年人的 EDC 暴露存在不同的关联。
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Association between food consumption and serum aryl hydrocarbon receptor ligand activity among middle-aged Korean adults.

Background/objectives: The diet is an important route of exposure to endocrine-disrupting chemicals (EDCs). However, few studies have investigated the association between dietary intake and EDC exposure levels among Koreans. In an earlier study, we showed that the bioactivity of serum aryl hydrocarbon receptor ligands (AhRLs) could be a surrogate biomarker to indicate exposure to EDCs and that they inhibit mitochondrial function. We also found that the mitochondria-inhibiting substances (MIS) in serum ascertained by intracellular adenosine triphosphate (MIS-ATP) and reactive oxygen species (MIS-ROS) levels could be biomarkers of exposure to EDCs, as they showed a strong correlation with AhRL and the levels of EDCs in the blood. Here, we investigated the association between the consumption of specific foods and surrogate serum biomarkers for EDCs, namely AhRL, MIS-ATP, and MIS-ROS, among middle-aged Korean adults.

Subjects/methods: A total of 1,466 participants aged 45-76 yrs from the Ansung cohort of the Korean Genome and Epidemiology Study were included. Food consumption, including that of meat, fish, vegetables, and fruits, was measured using a semiquantitative food frequency questionnaire.

Results: Fish intake was positively associated with AhRL (β = 0.0035, P = 0.0166), whereas cruciferous vegetable intake was negatively associated with AhRL (β = -0.0007, P = 0.0488). Cruciferous vegetable intake was positively associated with the MIS-ATP levels (β = 0.0051, P = 0.0420). A higher intake of fish was significantly associated with an increased risk of high AhRL (tertile: odds ratio [OR], 1.49; 95% confidence intervals (CIs), 1.08-2.06; P for trend = 0.0305). In addition, the second-highest tertile of cruciferous vegetable intake had lower odds of high AhRL than the lowest tertile (OR, 0.73; 95% CIs, 0.54-0.97), although no significant linear trend was observed.

Conclusion: Consumption of different types of foods may be differentially associated with EDC exposure in middle-aged Korean adults.

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来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
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