生姜在缓解化疗患者恶心方面的作用。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.12669/pjms.40.9.8739
Zamin Abbas Syed, Ammad Fahim, Mahpara Safdar, Rafia Imtiaz
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引用次数: 0

摘要

目的接受化疗的癌症患者通常会面临各种副作用,其中最常见的是恶心和呕吐。生姜(Zingiber officinale)含有天然化合物,可加快新陈代谢,增加肠道蠕动。生姜传统上用于治疗胃肠道疾病。本研究旨在评估生姜在缓解化疗患者恶心方面的作用:这项交叉干预研究旨在评估生姜在缓解化疗患者恶心症状方面的作用。研究在伊斯兰堡希法国际医院化疗日间护理中心进行,样本量为 90 名患者,采用非概率方便抽样法。接受化疗的患者连续五天服用生姜(550 毫克,一天两次)。在下一个化疗周期,同样的患者服用相同颜色和重量的安慰剂胶囊,每天两次,连续服用五天。连续五天与患者和护理人员联系,询问化疗后的恶心情况。恶心和呕吐用罗兹量表进行测量:结果表明,服用生姜胶囊的患者在所有五天中的罗德评分均明显低于服用安慰剂的患者(P 值小于 0.05):结论:生姜能明显缓解化疗患者的恶心症状。生姜的天然止吐特性为减轻化疗后的恶心和呕吐提供了一种方便、安全的方法。
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Role of Ginger in management of nausea among patients receiving chemotherapy.

Objective: Cancer patients treated with chemotherapy often face variety of side effects, with nausea and vomiting being the most frequent. Ginger (Zingiber officinale), contains natural compounds that can speed up the metabolism and increase intestinal motility. It is traditionally used to treat gastrointestinal disorders. The objective of this study was to evaluate the role of ginger in management of nausea among patients receiving chemotherapy.

Methods: This crossover interventional study was conducted to evaluate the role of ginger in management of nausea among patients receiving chemotherapy. Study was carried out at chemotherapy daycare of Shifa International Hospital Islamabad, with a sample size of 90 patients, using non-probability convenient sampling. Patients undergoing chemotherapy were given the dose of ginger (550 mg twice a day) for five consecutive days. On the next chemo cycle the same patients were given the placebo capsules of same color and weight for two times a day for five days. Patients and attendants were contacted for five days and being asked about post-chemotherapy nausea. Nausea and vomiting were measured by Rhodes scale.

Results: Results showed that Rhodes score of patients taking Ginger capsules was significantly lower than those taking placebo (p-value < 0.05) in all the five days.

Conclusion: Ginger significantly managed the nausea among patients receiving chemotherapy. Its natural antiemetic properties provide a convenient and safe way to reduce the post-chemotherapy nausea and vomiting.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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