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引用次数: 0
摘要
基于训练免疫的疫苗（TIbV）是疫苗研究领域的一种新兴疫苗策略，指的是根据训练免疫（TI）原理设计的疫苗。训练免疫是指先天性免疫细胞在经过训练后再次受到刺激时会产生更强的免疫反应。TIbV 建立在 TI 概念之上，旨在通过训练宿主的先天免疫系统获得天然免疫记忆，从而增强对各种传染性病原体的抵抗力。这种方法旨在增强对各种传染病病原体的免疫力，包括传统疫苗未涵盖的病原体。本文回顾了 TIbV 的概念、机制、应用领域和未来前景，旨在为疫苗开发和设计提供一个新的视角。
[Current progress on trained immunity-based vaccines].
Trained immunity-based vaccines (TIbV) is an emerging vaccine strategy in the field of vaccine research, referring to vaccines designed based on the principles of trained immunity (TI). TI involves the enhanced immune response of innate immune cells upon re-stimulation after being trained. TIbV, built on the concept of TI, aims to enhance resistance to various infectious pathogens by training the host's innate immune system to acquire natural immune memory. This approach is designed to bolster immunity against a wide range of infectious agents, including those not covered by conventional vaccines. This article reviews the concepts, mechanisms, application areas, and future prospects of TIbV, intending to offer a new perspective for vaccine development and design.
期刊介绍：
Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.
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