螺旋静脉包裹皮瓣治疗疼痛性神经瘤的手术效果:病例系列分析。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-21 DOI:10.12659/AJCR.945014
Meirizal Meirizal, Karisa Kartika Sukotjo, A Faiz Huwaidi, Agung Susilo Lo
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引用次数: 0

摘要

背景神经瘤引起的神经病理性疼痛症状给患者造成身体负担,并影响其精神和社会经济状况。与保守疗法相比,手术干预更有希望取得疗效。神经瘤切除术加上神经包膜瓣是一种既方便又经济的手术治疗方法。然而,很少有报告详细介绍这种方法的疗效。在本研究中,我们报告了 4 位接受神经瘤切除术和静脉自体皮瓣神经包裹术的患者。病例报告 我们介绍了 4 位经历过持续性神经痛且保守治疗超过 6 个月仍无效的患者。三名患者的上肢神经瘤为连续性神经瘤,一名患者的股神经瘤为残端神经瘤。手术治疗包括神经瘤切除、神经移植以及在吻合部位应用神经包裹瓣。对患者的评估包括神经瘤疼痛评分和韦伯两点辨别测试。随访评估显示临床症状明显改善,所有患者的疼痛均减轻了 60%,2 点辨别力平均提高了 5 毫米。没有发现复发或需要进一步手术的情况。结论 对于疼痛性神经瘤患者,手术治疗优于保守治疗。神经包裹瓣是治疗神经瘤的手术方法之一,是治疗连续性神经瘤和残端神经瘤的有效手术选择。这与神经末端闭合后,神经再生过程更加生理性有关。使用自体移植静脉作为闭合神经末端的材料之一,因其价格低廉、可容纳不同大小的神经而具有优势。
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Surgical Outcomes of Spiral Vein Wrapping Flaps for Painful Neuromas: A Case Series Analysis.

BACKGROUND Neuropathic pain symptoms caused by neuromas impose physical burdens and affect patients mentally and socioeconomically. Surgical intervention offers more promising outcomes than do conservative approaches. An accessible and cost-effective surgical treatments is neuroma excision, coupled with nerve wrapping flaps. However, few reports have detailed the outcomes of this approach. In this study, we report 4 patients who underwent neuroma excision and nerve wrapping with vein autographs. CASE REPORT We present 4 patients who experienced persistent neuropathic pain and did not respond to conservative treatment for more than 6 months. Three patients had upper limb neuromas in continuity and 1 patient had a stump femoral neuroma. Surgical intervention involved neuroma excision, nerve grafting, and the application of nerve wrapping flaps at the site of anastomosis. Evaluation of our patients included neuroma pain scores and the Weber 2-point discrimination test. Follow-up assessments demonstrated significant clinical improvement, with all patients showing up to 60% reduction in pain and an average improvement of 5 mm in 2-point discrimination. No recurrence or need for further surgery was observed. CONCLUSIONS Surgical intervention was superior to conservative treatment in patients with painful neuromas. Nerve wrapping flaps, one of the surgical procedures for neuroma management, represents an effective surgical option for neuromas in continuity and stump neuromas. This is related to the more physiological nerve regeneration process when nerve ends are closed. The use of autograft veins as one of the materials for closing nerve ends is advantageous owing to its affordability and versatility in accommodating nerves of varying sizes.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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