压电通道在疼痛中的作用机制和潜在治疗目标。

IF 2.5 Q2 CLINICAL NEUROLOGY Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.3389/fpain.2024.1452389
Yi Xu, Yuheng Wang, Shuchong Mei, Jialing Hu, Lidong Wu, Luyang Xu, Lijie Bao, Xiaowei Fang
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引用次数: 0

摘要

疼痛是许多临床疾病的常见症状,它对患者的身心健康造成不利影响,降低患者的生活质量,给患者和社会带来沉重负担。疼痛治疗是当今最棘手的问题之一。为提高疼痛的诊断和治疗率,探索疼痛发病机制的潜在因素迫在眉睫。Piezo1/2是一种新发现的机械敏感性离子通道,在机械刺激下开放,在调节疼痛相关疾病中起着关键作用。抑制或下调 Piezo1/2 可减轻疾病引起的疼痛。因此,在本研究中,我们全面讨论了该基因的生物学特性,重点研究了其在疼痛相关疾病中的潜在相关性,并探讨了使用该基因药物治疗疼痛的药理作用。
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The mechanism and potential therapeutic target of piezo channels in pain.

Pain is a common symptom of many clinical diseases; it adversely affects patients' physical and mental health, reduces their quality of life, and heavily burdens patients and society. Pain treatment is one of the most difficult problems today. There is an urgent need to explore the potential factors involved in the pathogenesis of pain to improve its diagnosis and treatment rate. Piezo1/2, a newly identified mechanosensitive ion channel opens in response to mechanical stimuli and plays a critical role in regulating pain-related diseases. Inhibition or downregulation of Piezo1/2 alleviates disease-induced pain. Therefore, in this study, we comprehensively discussed the biology of this gene, focusing on its potential relevance in pain-related diseases, and explored the pharmacological effects of drugs using this gene for the treatment of pain.

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13 weeks
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