碘（III）介导的光化学 C-H 叠氮反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-10-23 DOI:10.1021/acs.orglett.4c03490

Xuanzhen Han, Wenjie Yue, Zhixin Wang, Hanxiao Xu, Mengjie Yang, Jin Zhu

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引用次数: 0

摘要

本文制定了一个系统的自由基极性分析框架，用于预测自由基的反应模式。根据这套经验指南，设想并开发了一种碘（III）介导的光化学 C-H 叠氮化反应。该合成方法采用对环境无害的试剂、温和的反应条件、简单的操作程序和广泛的底物范围。该反应可用于醚、硫醚、酰胺、苄基和烯丙基 C-H 键，具有广泛的合成用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Iodine(III)-Mediated Photochemical C–H Azolation

A systematic radical polarity analysis framework is formulated herein for the projection of radical reactivity patterns. An iodine(III)-mediated photochemical C–H azolation reaction has been envisaged and developed based on the set of empirical guidelines. The synthesis features an environmentally benign reagent, mild reaction conditions, an operationally simple protocol, and a broad substrate scope. The inclusive demonstration of reactivity for ether, thioether, amide, benzylic, and allylic C–H bonds promises wide-ranging synthetic utility.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.