绣线菊(Filipendula ulmaria)干酊剂的 DNA 保护、抗氧化和抗致癌性潜力。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-10-03 DOI:10.3390/antiox13101200
Tsvetelina Andonova, Yordan Muhovski, Elena Apostolova, Samir Naimov, Silviya Mladenova, Iliya Slavov, Ivayla Dincheva, Vasil Georgiev, Atanas Pavlov, Ivanka Dimitrova-Dyulgerova
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引用次数: 0

摘要

如今,人们对天然抗氧化剂(尤其是酚类物质)预防氧化应激相关疾病的兴趣与日俱增,因为与某些合成类似物相比,天然抗氧化剂的副作用更小,活性更强。对知名草药物质进行新的化学和药理研究是当前药用植物研究的趋势之一。绣线菊(Filipendula ulmaria)是一种传统医学中常用的草药,可用于治疗多种疾病(包括风湿、炎症和肿瘤相关疾病等)。从保加利亚植物区系中采集的 Filipendulae ulmariae 草药干酊剂采用高效液相色谱法进行了分析,并进行了抗氧化、抗增殖和保护 DNA 免受氧化损伤的生物测定。高效液相色谱酚类谱图显示有 12 种酚类物质,其中水杨酸(18.84 毫克/克干提取物)、芦丁(9.97 毫克/克de)、对香豆酸(6.80 毫克/克de)、槲皮素(4.47 毫克/克de)、迷迭香酸(4.01 毫克/克de)和香草酸(3.82 毫克/克de)是主要成分。通过四种方法证实了该物种的高抗氧化潜力,其中以 CUPRAC 分析法的结果(10,605.91 μM TE/g de)最能说明问题。本研究首次报道了绣线菊干酊剂对 DNA 氧化损伤的高度保护活性及其对肝细胞癌(HepG2 细胞系)的抗增殖作用。绣线菊干酊剂在预防氧化应激引起的疾病方面具有巨大潜力。
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DNA-Protective, Antioxidant and Anti-Carcinogenic Potential of Meadowsweet (Filipendula ulmaria) Dry Tincture.

Nowadays, interest in natural antioxidants (especially phenolics) for the prevention of oxidative stress-related diseases is increasing due to their fewer side effects and more potent activity than some of their synthetic analogues. New chemical and pharmacological studies of well-known herbal substances are among the current trends in medicinal plant research. Meadowsweet (Filipendula ulmaria) is a popular herb used in traditional medicine to treat various diseases (including rheumatic-, inflammatory- and tumor-related disease, etc.). The dry tincture of Filipendulae ulmariae herba, collected from the Bulgarian flora, was analyzed using the HPLC method and bioassayed for antioxidant, antiproliferative and DNA-protective activities against oxidative damage. The HPLC phenolic profile showed 12 phenolics, of which salicylic acid (18.84 mg/g dry extract), rutin (9.97 mg/g de), p-coumaric acid (6.80 mg/g de), quercetin (4.47 mg/g de), rosmarinic acid (4.01 mg/g de) and vanillic acid (3.82 mg/g de) were the major components. The high antioxidant potential of the species was confirmed by using four methods, best expressed by the results of the CUPRAC assay (10,605.91 μM TE/g de). The present study reports for the first time the highly protective activities of meadowsweet dry tincture against oxidative DNA damage and its antiproliferative effect against hepatocellular carcinoma (HepG2 cell line). Meadowsweet dry tincture possesses great potential to prevent diseases caused by oxidative stress.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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