SUMO 家族:SUMO家族:甲状腺癌发病和治疗的机制及影响

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomedicines Pub Date : 2024-10-21 DOI:10.3390/biomedicines12102408
Bahejuan Jiaerken, Wei Liu, Jiaojiao Zheng, Weifeng Qu, Qiao Wu, Zhilong Ai
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引用次数: 0

摘要

(1) 背景:小泛素样修饰子(SUMOs)在翻译后修饰中起着关键作用,影响着蛋白质定位、稳定性和基因组完整性等各种细胞过程。(2) 方法:本综述探讨了 SUMO 家族,包括其同工型和催化循环,强调了它们在调节甲状腺癌关键生物学功能中的重要作用。我们讨论了 SUMOylation 在 DNA 修复机制、蛋白质稳定性和受体活性调节中的多方面作用,尤其是在甲状腺癌中的作用。(3) 结果:异常的 SUMOylation 机制通过改变基因表达和免疫逃避机制促进肿瘤发生。此外,我们还研究了在甲状腺癌治疗中靶向 SUMOylation 通路的治疗潜力,强调了进一步研究开发有效 SUMOylation 抑制剂的必要性。(4) 结论:通过了解 SUMOylation 在癌症生物学中的复杂作用,我们可以为创新治疗策略铺平道路,从而改善晚期肿瘤患者的预后。
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The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy.

(1) Background: Small ubiquitin-like modifiers (SUMOs) are pivotal in post-translational modifications, influencing various cellular processes, such as protein localization, stability, and genome integrity. (2) Methods: This review explores the SUMO family, including its isoforms and catalytic cycle, highlighting their significance in regulating key biological functions in thyroid cancer. We discuss the multifaceted roles of SUMOylation in DNA repair mechanisms, protein stability, and the modulation of receptor activities, particularly in the context of thyroid cancer. (3) Results: The aberrant SUMOylation machinery contributes to tumorigenesis through altered gene expression and immune evasion mechanisms. Furthermore, we examine the therapeutic potential of targeting SUMOylation pathways in thyroid cancer treatment, emphasizing the need for further research to develop effective SUMOylation inhibitors. (4) Conclusions: By understanding the intricate roles of SUMOylation in cancer biology, we can pave the way for innovative therapeutic strategies to improve outcomes for patients with advanced tumors.

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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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