体弱老年人体内循环硬骨素水平升高:骨健康之外的影响

IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Pub Date : 2024-10-24 DOI:10.3803/EnM.2024.2100
Ji Yeon Baek, Seong Hee Ahn, Il-Young Jang, Hee-Won Jung, Eunhye Ji, So Jeong Park, Yunju Jo, Eunju Lee, Dongryeol Ryu, Seongbin Hong, Beom-Jun Kim
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引用次数: 0

摘要

背景:硬骨蛋白最初被认为在骨代谢中起着关键作用,但因其对人体整体健康的多方面影响而备受关注。然而,它对虚弱--一种最能反映生理年龄的状况--的影响尚未得到深入研究:方法:我们采集了 244 名接受了综合老年评估的老年人的血液样本。方法:我们采集了 244 名接受了综合老年评估的老年人的血液样本,并使用酶联免疫吸附测定法对硬骨蛋白水平进行了量化。采用两种经过验证的方法评估虚弱程度:弗里德的表型模型和洛克伍德的虚弱指数(FI):结果:在控制了性别、年龄和体重指数后,我们发现体弱者的血清硬骨蛋白水平明显高于健壮者(PC结论:这些研究结果是首次发现体弱者的血清硬骨蛋白水平高于健壮者:这些研究结果首次探讨了循环硬骨素水平与虚弱之间的关系,具有重要的临床意义,将硬骨素定位为潜在的基于血液的虚弱生物标志物之一,它能全面捕捉老年人的身体、精神和社会方面,超越了其在骨代谢中的传统作用。
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Elevated Circulating Sclerostin Levels in Frail Older Adults: Implications beyond Bone Health.

Background: Sclerostin, initially recognized for its pivotal role in bone metabolism, has gained attention for its multifaceted impact on overall human health. However, its influence on frailty-a condition that best reflects biological age-has not been thoroughly investigated.

Methods: We collected blood samples from 244 older adults who underwent comprehensive geriatric assessments. Sclerostin levels were quantified using an enzyme-linked immunosorbent assay. Frailty was assessed using two validated approaches: the phenotypic model by Fried and the deficit accumulation frailty index (FI) by Rockwood.

Results: After controlling for sex, age, and body mass index, we found that serum sclerostin levels were significantly elevated in frail individuals compared to their robust counterparts (P<0.001). There was a positive correlation between serum sclerostin concentrations and the FI (P<0.001). Each standard deviation increase in serum sclerostin was associated with an odds ratio of 1.87 for frailty (P=0.003). Moreover, participants in the highest quartile of sclerostin levels had a significantly higher FI and a 9.91-fold increased odds of frailty compared to those in the lowest quartile (P=0.003 and P=0.039, respectively).

Conclusion: These findings, which for the first time explore the association between circulating sclerostin levels and frailty, have significant clinical implications, positioning sclerostin as one of potential blood-based biomarkers for frailty that captures the comprehensive physical, mental, and social aspects of the elderly, extending beyond its traditional role in bone metabolism.

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来源期刊
Endocrinology and Metabolism
Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.60
自引率
5.90%
发文量
145
审稿时长
24 weeks
期刊介绍: The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).
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