{"title":"头孢他啶联合疗法治疗耐甲氧西林凝固酶阴性葡萄球菌菌血症和心内膜炎。","authors":"Sunish Shah, Lloyd Clarke, Simi Padival","doi":"10.1136/ejhpharm-2024-004334","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>We report our experience with the use of ceftaroline in combination with daptomycin or vancomycin for methicillin resistant coagulase negative <i>Staphylococcus</i> bacteraemia.</p><p><strong>Methods: </strong>A multicentre retrospective study was carried out at three institutions of adult patients with methicillin resistant <i>S. epidermidis</i> or <i>S. lugdunensis</i> bacteraemia who were managed with either daptomycin or vancomycin in combination with ceftaroline.</p><p><strong>Results: </strong>Twelve patients met the inclusion criteria. All patients who received combination therapy had sterile blood cultures on the subsequent blood cultures drawn following ceftaroline initiation. Those who received ceftaroline combination within 7 days had a faster time to blood culture sterilisation than those who received ceftaroline combination therapy after 7 days (6 (3-7) days vs 17 (12-19) days, p=0.031).</p><p><strong>Conclusions: </strong>The results from this case series support the use of ceftaroline combination therapy in patients with methicillin resistant coagulase negative <i>Staphylococcus</i> bacteraemia whose blood cultures failed to sterilise with vancomycin or daptomycin alone.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ceftaroline combination therapy for methicillin resistant coagulase negative <i>Staphylococcus</i> bacteraemia and endocarditis.\",\"authors\":\"Sunish Shah, Lloyd Clarke, Simi Padival\",\"doi\":\"10.1136/ejhpharm-2024-004334\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>We report our experience with the use of ceftaroline in combination with daptomycin or vancomycin for methicillin resistant coagulase negative <i>Staphylococcus</i> bacteraemia.</p><p><strong>Methods: </strong>A multicentre retrospective study was carried out at three institutions of adult patients with methicillin resistant <i>S. epidermidis</i> or <i>S. lugdunensis</i> bacteraemia who were managed with either daptomycin or vancomycin in combination with ceftaroline.</p><p><strong>Results: </strong>Twelve patients met the inclusion criteria. All patients who received combination therapy had sterile blood cultures on the subsequent blood cultures drawn following ceftaroline initiation. Those who received ceftaroline combination within 7 days had a faster time to blood culture sterilisation than those who received ceftaroline combination therapy after 7 days (6 (3-7) days vs 17 (12-19) days, p=0.031).</p><p><strong>Conclusions: </strong>The results from this case series support the use of ceftaroline combination therapy in patients with methicillin resistant coagulase negative <i>Staphylococcus</i> bacteraemia whose blood cultures failed to sterilise with vancomycin or daptomycin alone.</p>\",\"PeriodicalId\":12050,\"journal\":{\"name\":\"European journal of hospital pharmacy : science and practice\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-10-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of hospital pharmacy : science and practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/ejhpharm-2024-004334\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of hospital pharmacy : science and practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/ejhpharm-2024-004334","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Ceftaroline combination therapy for methicillin resistant coagulase negative Staphylococcus bacteraemia and endocarditis.
Objective: We report our experience with the use of ceftaroline in combination with daptomycin or vancomycin for methicillin resistant coagulase negative Staphylococcus bacteraemia.
Methods: A multicentre retrospective study was carried out at three institutions of adult patients with methicillin resistant S. epidermidis or S. lugdunensis bacteraemia who were managed with either daptomycin or vancomycin in combination with ceftaroline.
Results: Twelve patients met the inclusion criteria. All patients who received combination therapy had sterile blood cultures on the subsequent blood cultures drawn following ceftaroline initiation. Those who received ceftaroline combination within 7 days had a faster time to blood culture sterilisation than those who received ceftaroline combination therapy after 7 days (6 (3-7) days vs 17 (12-19) days, p=0.031).
Conclusions: The results from this case series support the use of ceftaroline combination therapy in patients with methicillin resistant coagulase negative Staphylococcus bacteraemia whose blood cultures failed to sterilise with vancomycin or daptomycin alone.
期刊介绍：
European Journal of Hospital Pharmacy (EJHP) offers a high quality, peer-reviewed platform for the publication of practical and innovative research which aims to strengthen the profile and professional status of hospital pharmacists. EJHP is committed to being the leading journal on all aspects of hospital pharmacy, thereby advancing the science, practice and profession of hospital pharmacy. The journal aims to become a major source for education and inspiration to improve practice and the standard of patient care in hospitals and related institutions worldwide.
EJHP is the only official journal of the European Association of Hospital Pharmacists.
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