维达列汀共轭单金属纳米颗粒和双金属纳米复合材料对糖尿病引起的认知缺陷的影响

IF 4.6 2区 医学 Q1 NEUROSCIENCES Experimental Neurology Pub Date : 2024-10-24 DOI:10.1016/j.expneurol.2024.115026
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引用次数: 0

摘要

氧化应激是导致糖尿病、心血管疾病、神经退行性疾病和癌症等不同代谢疾病的主要原因之一。一些代谢性疾病,如糖尿病,会导致微血管和大血管并发症后的继发性并发症。一些最常见的神经退行性疾病,如认知障碍和阿尔茨海默氏症,都是在慢性糖尿病患者中发现的。本研究旨在利用阿脲诱导的大鼠认知障碍模型,了解糖尿病与认知障碍之间的相互联系机制。一水阿脲会产生活性氧,产生超氧自由基、过氧化氢和羟自由基。羟自由基最终导致β细胞死亡,引发糖尿病。因此,认知障碍中氧化应激与神经变性的相关性是本研究的导火索。在本研究中,我们探讨了维达列汀(VLD)及其共轭纳米粒子对氧化应激导致的阿脲相关脑损伤的改善作用。研究人员合成了维达列汀的金(Au)、硒(Se)纳米颗粒和双金属(Se@Au)纳米复合材料,并评估了它们对大脑可用性的改善作用。使用 DPPH、ABTS 和 FRAP 法对 VLD 和纳米颗粒进行了体外抗氧化评估。对大鼠大脑进行了与记忆相关的神经行为研究、体内抗氧化研究、体内生化研究和组织病理学检查。结果表明,VLD 及其纳米制剂在体外和体内抗氧化性方面均有显著的表现(p
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Effect of vildagliptin conjugated monometallic nanoparticles and bimetallic nanocomposites on diabetes-induced cognitive deficit
Oxidative stress is one of the major causes of different metabolic disorders, including diabetes, cardiovascular diseases, neurodegenerative diseases and cancers. Some metabolic disorders like diabetes mellitus leads to secondary complications after micro and macrovascular complications. Some of the most prevalent neurodegenerative diseases, like cognitive impairment and Alzheimer's disease, are found in chronic diabetic patients. The present study is designed to understand the mechanism of interconnection between diabetes mellitus and cognitive deficit using the alloxan model of diabetes-induced cognitive deficit in the rat model. The alloxan monohydrate produces reactive oxygen species, producing superoxide free radicals, hydrogen peroxide and hydroxyl radicals. The hydroxyl radicals ultimately cause the death of beta cells, causing diabetes. Hence, the correlation of oxidative stress and neurodegeneration in cognitive impairment is the trigger for this study. In the present study, we investigate the ameliorative effect of vildagliptin (VLD) and its conjugated nanoparticles against alloxan-associated brain damage due to oxidative stress. The gold (Au), selenium (Se) nanoparticles, and bimetallic (Se@Au) nanocomposites of VLD are synthesized and assessed for improvement in their brain availability. The in-vitro antioxidant evaluation of the VLD and nanoparticles is done using DPPH, ABTS, and FRAP assay. The memory-related neurobehavioral studies, in-vivo antioxidant studies, in-vivo biochemical studies, and histopathological examinations are evaluated in rat brains. The VLD and its nanoformulations exhibited in-vitro and in-vivo antioxidant properties significantly (p < 0.01). They reduced the activity of AChE and nitrite in the alloxan diabetic rats. The bimetallic Se@Au VLDNCs displayed a more protective effect than VLD, VLD–AuNPs, and VLD–SeNPs.
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来源期刊
Experimental Neurology
Experimental Neurology 医学-神经科学
CiteScore
10.10
自引率
3.80%
发文量
258
审稿时长
42 days
期刊介绍: Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.
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