ACTIV 试验的具体经验教训概述。

IF 2.1 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical and Translational Science Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.1017/cts.2023.698
Ruxandra Draghia-Akli, Sarah W Read, Eric A Hughes
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引用次数: 0

摘要

加速 COVID-19 治疗干预和疫苗(ACTIV)是公私合作伙伴关系(PPP)的一个杰出范例,它汇集了三十多个组织和数百名个人,以解决近几十年来最紧迫的全球健康需求之一。特别是,ACTIV 为测试多种治疗方法提供了重要途径,以确定这些方法对治疗 SARS-CoV-2 病毒或急性 COVID-19 感染症状的潜在益处。考虑到 ACTIV 在其同时努力创建的全球网络中设计和实施主协议的速度和规模,PPP 可以为下一次全球面临新型病原体大流行时的最佳实践和避免陷阱提供宝贵的经验。本报告对 ACTIV 合作伙伴关系进行了总体概述,为本期后续文章介绍这些经验教训奠定了基础和背景。
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Overview of ACTIV trial-specific lessons learned.

Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) was an extraordinary example of a public-private partnership (PPP) that brought together over thirty organizations and hundreds of individuals to address one of the most pressing global health needs in recent decades. In particular, ACTIV provided a key avenue for testing numerous therapeutics for their potential benefit in treating the SARS-CoV-2 virus or the resulting symptoms of acute COVID-19 infection. Given the speed and scale at which ACTIV designed and implemented master protocols across global networks that it was simultaneously working to create, the PPP can provide valuable lessons for best practices and avoiding pitfalls the next time the world is faced with a global pandemic of a novel pathogen. This report provides a general overview of the ACTIV partnership to set the stage and context for the subsequent articles in this issue that will relay these lessons learned.

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来源期刊
Journal of Clinical and Translational Science
Journal of Clinical and Translational Science MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
2.80
自引率
26.90%
发文量
437
审稿时长
18 weeks
期刊最新文献
Overview of ACTIV trial-specific lessons learned. Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future. The future is now: Using the lessons learned from the ACTIV COVID-19 therapeutics trials to create an inclusive and efficient clinical trials enterprise. ACTIV trials: Lessons learned in trial design in the setting of an emergent pandemic. Realizing the potential of social determinants data in EHR systems: A scoping review of approaches for screening, linkage, extraction, analysis, and interventions.
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