Hao Kong, Qingxin Yang, Chunwei Wu, Xiangji Wu, Xinrui Yan, Li-Bin Huang, Lu Chen, Zong-Guang Zhou, Ping Wang, Hong Jiang
{"title":"免疫检查点的空间背景是可切除结直肠癌患者总生存期的预测因素,与标准 TNM 分期无关。","authors":"Hao Kong, Qingxin Yang, Chunwei Wu, Xiangji Wu, Xinrui Yan, Li-Bin Huang, Lu Chen, Zong-Guang Zhou, Ping Wang, Hong Jiang","doi":"10.1158/2767-9764.CRC-24-0270","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>The identification of specific spatial patterns of immune checkpoint expression that correlate with overall survival in patients with colon cancer suggests a potential prognostic tool for risk stratification and treatment selection. These findings pave the way for the development of novel therapeutic strategies to enhance antitumor immune responses.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3025-3035"},"PeriodicalIF":3.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589669/pdf/","citationCount":"0","resultStr":"{\"title\":\"Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor-Node-Metastasis Stages.\",\"authors\":\"Hao Kong, Qingxin Yang, Chunwei Wu, Xiangji Wu, Xinrui Yan, Li-Bin Huang, Lu Chen, Zong-Guang Zhou, Ping Wang, Hong Jiang\",\"doi\":\"10.1158/2767-9764.CRC-24-0270\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Significance: </strong>The identification of specific spatial patterns of immune checkpoint expression that correlate with overall survival in patients with colon cancer suggests a potential prognostic tool for risk stratification and treatment selection. These findings pave the way for the development of novel therapeutic strategies to enhance antitumor immune responses.</p>\",\"PeriodicalId\":72516,\"journal\":{\"name\":\"Cancer research communications\",\"volume\":\" \",\"pages\":\"3025-3035\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589669/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/2767-9764.CRC-24-0270\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0270","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor-Node-Metastasis Stages.
Significance: The identification of specific spatial patterns of immune checkpoint expression that correlate with overall survival in patients with colon cancer suggests a potential prognostic tool for risk stratification and treatment selection. These findings pave the way for the development of novel therapeutic strategies to enhance antitumor immune responses.