电喷雾离子化用熔融石英纳米喷雾发射器的修整

IF 1 4区 化学 Q4 CHEMISTRY, ANALYTICAL Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI:10.1134/S1061934824701028
J. E. Thompson
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引用次数: 0

摘要

熔融石英喷嘴产生稳定的电喷雾对质谱分析至关重要,但这些喷嘴会降解,导致液滴形成和喷雾效果不佳。目前已开发出一种快速、经济有效的方法来使这些吸头恢复活力,从而延长其可用性并降低成本。该方法包括用丙酮、水、氢氧化钠水溶液、水和丙酮依次冲洗已拔出的电喷雾电离(ESI)熔融石英发射器,然后风干。接着,将针尖浸入羟基封端聚二甲基硅氧烷溶液中,然后风干。最后进行丙酮冲洗即可完成整个过程,无需拆卸流体流动系统或将 nESI 喷嘴从支架上取下。这种修整不仅能防止液滴的形成,还能恢复正确的喷雾模式,确保电喷雾在 1-2 周内保持稳定。喷嘴可以进行多次修整。虽然该规程可能会导致瞬时污染物峰,但这些污染物峰会在 24 小时内逐渐减少,我们还提供了一份潜在污染物清单。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Reconditioning of Fused Silica Nanospray Emitters for Electrospray Ionization

Stable electrospray generation from fused silica tips is critical for mass spectrometry, but these tips can degrade, leading to droplet formation and poor spray. A quick, cost-effective method has been developed to rejuvenate these tips, extending their usability and reducing expenses. The protocol involves sequentially rinsing pulled fused silica emitters for electrospray ionization (ESI) with acetone, water, an aqueous sodium hydroxide solution, water, and acetone again, followed by air drying. Next, the tip is dipped into a hydroxy-terminated polydimethylsiloxane solution and air dried. A final acetone rinse completes the process, which does not require disassembling the fluidic flow system or removing the nESI tip from its mount. This reconditioning not only prevents droplet formation but also restores the correct spray pattern, ensuring stable electrospray for 1–2 weeks. Tips can undergo multiple reconditionings. Although the protocol may lead to transient contaminant peaks, these diminish over 24 hours, and a list of potential contaminants is provided.

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来源期刊
Journal of Analytical Chemistry
Journal of Analytical Chemistry 化学-分析化学
CiteScore
2.10
自引率
9.10%
发文量
146
审稿时长
13 months
期刊介绍: The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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