Stela Carpini-Dantas, Gil Guerra-Junior, Andréa Trevas Maciel-Guerra, Denise Barbieri Marmo, Tarsis Paiva Vieira, Carolina Paniago Lopes, Maria Tereza Matias Baptista, André Moreno Morcillo, Sofia Helena Valente de Lemos-Marini
{"title":"巴西特纳综合征女孩在未使用促生长激素或奥昔诺龙的情况下的生长图表。","authors":"Stela Carpini-Dantas, Gil Guerra-Junior, Andréa Trevas Maciel-Guerra, Denise Barbieri Marmo, Tarsis Paiva Vieira, Carolina Paniago Lopes, Maria Tereza Matias Baptista, André Moreno Morcillo, Sofia Helena Valente de Lemos-Marini","doi":"10.1016/j.jped.2024.09.003","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.</p><p><strong>Methods: </strong>This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the \"GAMLSS\" package of the \"R\" software was used.</p><p><strong>Results: </strong>The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.</p><p><strong>Conclusion: </strong>These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.</p>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone.\",\"authors\":\"Stela Carpini-Dantas, Gil Guerra-Junior, Andréa Trevas Maciel-Guerra, Denise Barbieri Marmo, Tarsis Paiva Vieira, Carolina Paniago Lopes, Maria Tereza Matias Baptista, André Moreno Morcillo, Sofia Helena Valente de Lemos-Marini\",\"doi\":\"10.1016/j.jped.2024.09.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.</p><p><strong>Methods: </strong>This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the \\\"GAMLSS\\\" package of the \\\"R\\\" software was used.</p><p><strong>Results: </strong>The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.</p><p><strong>Conclusion: </strong>These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.</p>\",\"PeriodicalId\":14867,\"journal\":{\"name\":\"Jornal de pediatria\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jornal de pediatria\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jped.2024.09.003\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jornal de pediatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jped.2024.09.003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone.
Objective: The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.
Methods: This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the "GAMLSS" package of the "R" software was used.
Results: The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.
Conclusion: These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.
期刊介绍：
Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.
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