{"title":"利用合成磁共振成像和质子密度脂肪分数分析对年轻患者腰背痛风险因素进行定量评估。","authors":"Yuan Yang, Wu-Sheng Lin, Hui-Quan Wen, Xiao-Wen Luo, Xiang Zhou, Feng-Yun Zou, Shuang-Shuang Zhong, Ya-Yin Deng, Li-Shan Shen, Yong Zhang, Qing-Ling Li, Ruo-Mi Guo","doi":"10.1177/20406223241293260","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lumbar intervertebral disc and paravertebral muscle degeneration are common causes of chronic low back pain (CLBP). However, the exact etiology of CLBP in young patients remains unclear. Identifying the risk factors for CLBP in young patients could expedite the development of effective preventive recommendations.</p><p><strong>Objectives: </strong>To identify the factors influencing the presence and severity of CLBP in young patients by analyzing the associations between the fat content of the paravertebral muscles, T2 value of the lumbar intervertebral disc (LIVD), and visual analog scale (VAS) score.</p><p><strong>Design: </strong>Data for 23 patients diagnosed with CLBP were compared to those of 20 healthy young individuals.</p><p><strong>Methods: </strong>The T2 values of the LIVD and fat content of the psoas major (PM), multifidus (MF), and erector spinae (ES) muscles for 23 young patients with CLBP and 20 healthy individuals were measured and compared using synthetic magnetic resonance imaging and proton density fat fraction analyses. Moreover, the factors (T2 values and fat content) associated with severe CLBP (assessed using the VAS score) were analyzed.</p><p><strong>Results: </strong>The fat content of the right MF and ES was higher in patients with CLBP than in healthy individuals (<i>p</i> < 0.05). The T2 values of each LIVD in the CLBP and control groups were not significantly different (<i>p</i> > 0.05). Moreover, the VAS scores did not correlate with the T2 values of the patients (<i>p</i> > 0.05). The fat content of the bilateral MF and ES muscles was positively associated with the VAS score in young patients with CLBP (left MF: <i>r</i> = 0.506, <i>p</i> = 0.01; right MF: <i>r</i> = 0.532, <i>p</i> = 0.01; left ES: <i>r</i> = 0.636, <i>p</i> < 0.01; and right ES: <i>r</i> = 0.716, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Degeneration of the MF and ES may contribute to CLBP in young patients. In addition, the severity of CLBP is positively correlated with the degree of fat infiltration in the MF and ES.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"15 ","pages":"20406223241293260"},"PeriodicalIF":3.3000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528588/pdf/","citationCount":"0","resultStr":"{\"title\":\"Quantitative evaluation of risk factors for low back pain in young patients using synthetic magnetic resonance imaging and proton density fat fraction analyses.\",\"authors\":\"Yuan Yang, Wu-Sheng Lin, Hui-Quan Wen, Xiao-Wen Luo, Xiang Zhou, Feng-Yun Zou, Shuang-Shuang Zhong, Ya-Yin Deng, Li-Shan Shen, Yong Zhang, Qing-Ling Li, Ruo-Mi Guo\",\"doi\":\"10.1177/20406223241293260\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Lumbar intervertebral disc and paravertebral muscle degeneration are common causes of chronic low back pain (CLBP). However, the exact etiology of CLBP in young patients remains unclear. Identifying the risk factors for CLBP in young patients could expedite the development of effective preventive recommendations.</p><p><strong>Objectives: </strong>To identify the factors influencing the presence and severity of CLBP in young patients by analyzing the associations between the fat content of the paravertebral muscles, T2 value of the lumbar intervertebral disc (LIVD), and visual analog scale (VAS) score.</p><p><strong>Design: </strong>Data for 23 patients diagnosed with CLBP were compared to those of 20 healthy young individuals.</p><p><strong>Methods: </strong>The T2 values of the LIVD and fat content of the psoas major (PM), multifidus (MF), and erector spinae (ES) muscles for 23 young patients with CLBP and 20 healthy individuals were measured and compared using synthetic magnetic resonance imaging and proton density fat fraction analyses. Moreover, the factors (T2 values and fat content) associated with severe CLBP (assessed using the VAS score) were analyzed.</p><p><strong>Results: </strong>The fat content of the right MF and ES was higher in patients with CLBP than in healthy individuals (<i>p</i> < 0.05). The T2 values of each LIVD in the CLBP and control groups were not significantly different (<i>p</i> > 0.05). Moreover, the VAS scores did not correlate with the T2 values of the patients (<i>p</i> > 0.05). The fat content of the bilateral MF and ES muscles was positively associated with the VAS score in young patients with CLBP (left MF: <i>r</i> = 0.506, <i>p</i> = 0.01; right MF: <i>r</i> = 0.532, <i>p</i> = 0.01; left ES: <i>r</i> = 0.636, <i>p</i> < 0.01; and right ES: <i>r</i> = 0.716, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Degeneration of the MF and ES may contribute to CLBP in young patients. In addition, the severity of CLBP is positively correlated with the degree of fat infiltration in the MF and ES.</p>\",\"PeriodicalId\":22960,\"journal\":{\"name\":\"Therapeutic Advances in Chronic Disease\",\"volume\":\"15 \",\"pages\":\"20406223241293260\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-10-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528588/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Chronic Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/20406223241293260\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Chronic Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/20406223241293260","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
背景：腰椎间盘和椎旁肌肉退化是导致慢性腰背痛（CLBP）的常见原因。然而，年轻患者慢性腰背痛的确切病因仍不清楚。确定年轻患者患慢性腰背痛的风险因素可加快制定有效的预防建议：通过分析椎旁肌肉脂肪含量、腰椎间盘 T2 值（LIVD）和视觉模拟量表（VAS）评分之间的关联，确定影响年轻患者出现 CLBP 及其严重程度的因素：设计：将 23 名确诊为慢性腰椎间盘突出症的患者的数据与 20 名健康年轻人的数据进行比较：方法：通过合成磁共振成像和质子密度脂肪分数分析，测量并比较 23 名年轻的 CLBP 患者和 20 名健康人的腰大肌（PM）、多股肌（MF）和竖脊肌（ES）的 LIVD T2 值和脂肪含量。此外，还分析了与严重CLBP（使用VAS评分评估）相关的因素（T2值和脂肪含量）：结果：CLBP 患者右侧 MF 和 ES 的脂肪含量高于健康人（P > 0.05）。此外，VAS 评分与患者的 T2 值无相关性（P > 0.05）。在年轻的 CLBP 患者中，双侧 MF 和 ES 肌肉的脂肪含量与 VAS 评分呈正相关（左侧 MF：r = 0.506，p = 0.01；右侧 MF：r = 0.532，p = 0.01；左侧 ES：r = 0.636，p r = 0.716，p 结论：双侧 MF 和 ES 肌肉的脂肪含量与 VAS 评分呈正相关：MF 和 ES 的退化可能会导致年轻患者的 CLBP。此外，CLBP 的严重程度与 MF 和 ES 的脂肪浸润程度呈正相关。
Quantitative evaluation of risk factors for low back pain in young patients using synthetic magnetic resonance imaging and proton density fat fraction analyses.
Background: Lumbar intervertebral disc and paravertebral muscle degeneration are common causes of chronic low back pain (CLBP). However, the exact etiology of CLBP in young patients remains unclear. Identifying the risk factors for CLBP in young patients could expedite the development of effective preventive recommendations.
Objectives: To identify the factors influencing the presence and severity of CLBP in young patients by analyzing the associations between the fat content of the paravertebral muscles, T2 value of the lumbar intervertebral disc (LIVD), and visual analog scale (VAS) score.
Design: Data for 23 patients diagnosed with CLBP were compared to those of 20 healthy young individuals.
Methods: The T2 values of the LIVD and fat content of the psoas major (PM), multifidus (MF), and erector spinae (ES) muscles for 23 young patients with CLBP and 20 healthy individuals were measured and compared using synthetic magnetic resonance imaging and proton density fat fraction analyses. Moreover, the factors (T2 values and fat content) associated with severe CLBP (assessed using the VAS score) were analyzed.
Results: The fat content of the right MF and ES was higher in patients with CLBP than in healthy individuals (p < 0.05). The T2 values of each LIVD in the CLBP and control groups were not significantly different (p > 0.05). Moreover, the VAS scores did not correlate with the T2 values of the patients (p > 0.05). The fat content of the bilateral MF and ES muscles was positively associated with the VAS score in young patients with CLBP (left MF: r = 0.506, p = 0.01; right MF: r = 0.532, p = 0.01; left ES: r = 0.636, p < 0.01; and right ES: r = 0.716, p < 0.01).
Conclusion: Degeneration of the MF and ES may contribute to CLBP in young patients. In addition, the severity of CLBP is positively correlated with the degree of fat infiltration in the MF and ES.
期刊介绍：
Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area.
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